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| Experimental study on the changes of renal and systemic microcirculation induced by intra-abdominal hypertension |
| SUI Feng, ZHENG Yue, MA Wen-Liang, JIANG Yi-Jia, HUANG Li-Feng, ZHAO Song, LI Wen-Xiong |
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Abstract Objective Intra-abdominal hypertension（IAH）and abdominal compartment syndrome（ACS）are the common complications of patients in intensive care unit. When the intra-abdominal pressure（IAP）is increased, the perfusion of abdominal organs is decreased, and this is one of the causes of acute kidney injury（AKI）. The purpose of the study is to evaluate the renal cortical and sublingual microcirculation by sidestream dark field（SDF）imaging in the porcine model. Methods In 12 pigs, IAP was increased stepwise to 10, 15, 20, 25 mm Hg while hemodynamic parameters, urinary output, sublingual and renal SDF videos pictures were all recorded. Results With the increase of abdominal pressure sublingual MFI drop significantly, especially when IAP was higher than 20 mm Hg. But other parameters such as the total vascular density（TVD）, De Backer Score, proportion of perfused vessels （PPV）, perfused vessel density （PVD）, and heterogeneity index （HI） of tongue were not changed. With increasing IAP, MFI decreased about 30%. APP showed a moderate correlation with MFI（r＝0.64, P＜0.05）. Conclusion SDF on surface of kidney is a useful tool to evaluate the microcirculation of kidney.
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Received: 08 August 2016
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