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| The effects of sevoflurane on myocardial edema after cardio-pulmonary resuscitation in rats andthe discussion of aquaporin-1′s function |
| LI Heng-Jie, WEI Hong-Yan, LU Yuan-Zheng, YANG Yan, LI Bo, MAO Hui, CAI Wen-Wei, LIAO Xiao-Xing |
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Abstract Objective To investigate the effects of sevoflurane on myocardial edema after cardio-pulmonary resuscitation（CPR）in rats and discuss the function of aquaporin-1（AQP-1）in the formation and regression of myocardial edema. Methods The cardiac arrest model was established by induction of asphyxia. A total of 78 male Wistar rats were assigned to three groups randomly. Rats in the sham group were not induced to cardiac arrest. Rats in the sevo group inhaled 1MAC of sevoflurane during CPR. Rats in the control group operated the standard CPR. At first, the rats in the sevo group and control group were over anesthetic to death at baseline, ROSC 6 h, 12 h, 18 h, 24 h（each n＝4）, for measurement of water content in myocardium. Thereafter, at baseline, ROSC 1 h, ROSC 24 h, the rats in these three groups received the echocardiography examination. At ROSC 24 h, the rats were over anesthetic to death, the hearts were removed to detect the expression of AQP-1. Results After ROSC, the myocardial water content increased, which was lighter in the sevo group（P＜0.05）. At ROSC 1 h, the EF was decreased, the sevo group had a higher EF than the control group（P＜0.05）. At ROSC 24 h, the LVPW became thick and the EDV was decreased, the sevo group had a lighter thickness of LVPW and an enhanced EDV than the control group（P＜0.05）. The expression of myocardial AQP- 1 in protein and mRNA was decreased, the sevo group had a higher expression than the control group（P＜0.05）.Conclusion Sevoflurane can improve myocardial function after ROSC, attenuate the myocardial edema. The role of AQP-1, in the formation and regression of myocardial edema, is not completely clear.
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Received: 04 September 2016
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