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| Research progresses in the animal models of cardiac arrest |
| Sun Zhan-peng, Liao Xiao-xing |
| Department of Critical and Critical Medicine, Guangdong General Hospital(Guangdong Academy of Medical Sciences), Guangzhou 510080, China |
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Abstract Cardiac arrest (CA) and cardiopulmonary resuscitation(CPR) have long been the research hotspots in emergency medicine. Because of the sudden occurrence of CA, it is difficult to conduct clinical controlled trials, so animal experiments are indispensable. Establishing an animal CA model that can simulate the clinical maximum is an urgent problem. At present, experimental animals commonly used in CA and CPR research can be roughly divided into three groups: a small animal, such as a rat, etc.; a medium-sized animal, such as a domestic rabbit, etc.; a large animal, such as a pig, a dog, etc. As for the way of cardiac arrest, there are electric shock, asphyxia, and clamp the great vessels. In this paper, the basic requirements, types, manufacturing methods and characteristics of cardiopulmonary resuscitation animal models at home and abroad are reviewed.
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Corresponding Authors:
Liao Xiao-xing, E-mail:liaowens@163.com
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