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| A clinical random control trial on the clearance of lactic acid in septic shock patients |
| Luo Ya-jun, Liu Yin, Xue Xiao-yan |
| Intensive Care Unit, Aerospace Center Hospital, Beijing 100049, China |
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Abstract Objective To compare the effects of early goal-directed therapy (EGDT) and lactate clearance rate in septic shock patients. And to investigate whether the albumin should be used in the early stage of resuscitation.Methods A random control trial was conducted, in which patients satisfied with the criteria of septic shock diagnosis were enrolled. A total of 92 patients were randomly divided into two groups: EGDT group and Lactic acid group.Results There was no significant difference between the two groups in survival (death rate in ICU 13.3% vs. 15.6%,P=0.369; death rate in 90 d 35.6% vs. 36.2%, P=1.019), ventilation period［(93.8±32.0) h vs. (102.5±58.9) h,P=0.564)］, and ICU period ［(9.3±2.6) d vs. (8.8±3.1) d, P=0.656)］. While it was fewer in Lactic acid group than EGDT group ［(1861±114)mL vs. (1503±201) mL,P=0.098)］, and better APACHE Ⅱscore (EGDT group P=0.008, Lactic acid group P=0.034). In the early stage of resuscitation, albumin was beneficial for reducing fluid volume and time consuming.Conclusion Lactate clearance rate is a valid index for resuscitation in septic shock patients. Especially in the hospital without central venous catheterization, it should be take into account.
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| About author:: Luo Ya-jun, E-mail: yajun_luo@126.com |
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