高渗盐水治疗创伤性脑水肿——系统评价和Meta分析

doi:10.3969/j.issn.1002-1949.2018.05.002

Chinese Journal of Critical Care Medicine

2018, Vol. 38

Issue (5): 378- DOI: 10.3969/j.issn.1002-1949.2018.05.002

Hypertonic saline solutions in the treatment of traumatic cerebral swelling: a systematic review and meta-analysis

Di Bao-shan, Wang Hu, Tian Jin-hui, Zhang Xu, Ge Long, Yang Rong-jia, Zhu Bin, Li Xiao-long, Wei Xiao-dong, Zhang Dong-zhi, Liu Shao-guang, Ma Cong, Wen Xing-li, Guo Tian-kang

People′s Hospital of Gansu, Lanzhou 730000， China

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Abstract Objective To systematically assess the efficacy of hypertonic saline (HS)versus mannitol for traumatic cerebral swelling. Methods Databases including CBM, CNKI, Wanfang, PubMed, EMBASE.com, Web of Science, and the Cochrane Library databases were searched from inception to January, 2018. Literature selection, data extraction, and quality assessment were performed independently by two trained reviewers. STATA 12.0 software was used to analyze data. Results A total of 12 RCTs were included for systematic review and 8 for meta-analysis. The results of meta-analysis showed that there were no statistical significant differences in decreasing intracranial pressure ［WMD=-0.41, 95%CI（-1.11, 0.28）, P=0.240］and shorting onset time of drug ［SMD=0.11, 95%CI（-0.13, 0.34）, P=0.368］. However, the difference was statistical significant in duration of drug ［SMD=1.15, 95%CI（0.55, 1.75）, P=0.000］. Conclusion Compared with 20% mannitol, the efficacy is similar for 3.0% HS in decreasing intracranial pressure and shorting onset time of drug, and 3.0% HS is better in duration of drug. More investigations are needed for other different density HS.

Key words： Traumatic cerebral swelling Hypertonic saline(HS) Mannitol Systematic review Meta-analysis

Corresponding Authors: Guo Tian-kang, E-mail: guotiankang59@126.com

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	Articles by authors
	Di Bao-shan
	Wang Hu
	Tian Jin-hui
	Zhang Xu
	Ge Long
	Yang Rong-jia
	Zhu Bin
	Li Xiao-long
	Wei Xiao-dong
	Zhang Dong-zhi
	Liu Shao-guang
	Ma Cong
	Wen Xing-li
	Guo Tian-kang

Cite this article:

Di Bao-shan,Wang Hu,Tian Jin-hui, et al. Hypertonic saline solutions in the treatment of traumatic cerebral swelling: a systematic review and meta-analysis[J]. Chinese Journal of Critical Care Medicine, 2018, 38(5): 378-.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2018.05.002 OR http://www.cnemergency.org.cn/EN/Y2018/V38/I5/378

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