乌司他丁对脓毒症伴多器官衰竭患者血清降钙素原C反应蛋白及免疫功能的影响

doi:10.3969/j.issn.1002-1949.2018.04.011

Chinese Journal of Critical Care Medicine

2018, Vol. 38

Issue (4): 328- DOI: 10.3969/j.issn.1002-1949.2018.04.011

Effects of ulinastatin on serum procalcitonin, C reactive protein and immune function in patients with sepsis complicated with multiple organ failure

Zhang Kai-kai, Yu Xue-zhong, Liang Xian-quan, Yu Shan-shan

Guiyang Second People′s Hospital, Guiyang 550023, China

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Abstract Objective To analyze the effects of ulinastatin on serum procalcitonin (PCT), C reactive protein (CRP) and immune function in patients with sepsis complicated with multiple organ failure. Methods From March 2014 to March 2017, 157 cases of sepsis with multiple organ failure in intensive care unit of Guiyang Second People′s Hospital were retrospectively selected. According to drug use, it was divided into control group and observation group. The patients in the control group were treated with routine therapy, while the patients in the observation group were treated with routine therapy combined with ulinastatin. APACHEⅡ the score, the mortality rate within 1 months, immune function, heart function index, PCT, CRP, lipid peroxide (LPO) and monocyte human leukocyte antigen DR (HLA-DR) level changes in the patientswere observed and analyzed between the two groups. Results APACHEⅡ score of the two groups were improved compared with before treatment, patients in the observation group after treatment APACHEⅡ score than the control group (P＜0.05). After treatment, PCT, CRP, LPO, BNP, hla-dr and LVEF levels of the observation group were respectively (9.75±3.64) ng/mL, (9.11±3.91) mg/L, (4.10±1.69) EU/mL, (285.55±87.79) pg/mL, (26.94±4.02) %, (66.87±5.28) %; they were (9.87±3.55) ng/mL, (13.97±4.87) mg/L, (8.11±2.14) EU/mL, (311.01±95.25) pg/mL, (20.68±3.22) %, (55.48±6.34) %, respectively in control group; there were statistically significant differences in CRP, LPO, BNP, hla-dr and LVEF levels between the two groups, but there was no statistical difference in PCT level (P＞ 0.05).The level of immune function in the observation group was better than that in the control group (P＜0.05).The mortality of the patients in the observation group was 18.29 in one month and that in the control group was 44.00. The fatality rate in the observation group was lower than that in the control group (P＜0.05). Conclusion Ulinastatin adjuvant treatment of sepsis with multiple organ failure can improve the heart function of patients, regulate the level of immune indicators, reduce the serum levels of CRP and LPO, and reduce the short-term mortality.

Key words： Ulinastatin Sepsis complicated with multiple organ failure Cardiac function;　Immunity Procalcitonin (PCT)

Corresponding Authors: Yu Xue-zhong, E-mail:yxzpumch@126.com

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	Zhang Kai-kai
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	Yu Shan-shan

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Zhang Kai-kai,Yu Xue-zhong,Liang Xian-quan, et al. Effects of ulinastatin on serum procalcitonin, C reactive protein and immune function in patients with sepsis complicated with multiple organ failure[J]. Chinese Journal of Critical Care Medicine, 2018, 38(4): 328-.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2018.04.011 OR http://www.cnemergency.org.cn/EN/Y2018/V38/I4/328

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