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| The expression and clinical value of immune globulin in patients with AECOPD |
| Wu Yuan-xing, Huang Li-xue, Zhu Guang-fa |
| Department of Pulmonary and Critical Care Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China |
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Abstract Objective To investigate the expression and clinical value of immune globulin in patients with AECOPD. Methods One hundred and twenty-two COPD patients were divided into four groups accoding to the evaluation of acute exacerbation from Jan 2016 to Jan 2017. Twenty-two patients were in A group, 39 patients were in B group, 35 patients were in C group, 26 patients were in D group and and another 30 healthy subjects as the control group. IgA,IgM, IgG, IgE and ALB were detected. Results There were significant differences in IgA, IgG, IgM and ALB among the five groups (P<0.05). Comparison of IgE in group B and C and was higher than that in health group, respectively P values 0.007, <0.001; comparison of IgA in the group A, B and D was lower than that in health group, respectively P values<0.001, 0.005, 0.036; comparison of IgG in the group A, B and D was lower than that in health group, respectively P values 0.004, <0.001, 0.001;comparison of IgM in the group A and B was lower than that in health group, respectively P values 0.004, <0.001; comparison of ALB in A, B, C and D group were all lower than that in health group, P<0.001. Conclusion Humoral immune dysfunction exists in COPD patients, at the same time, there is an increase in IgE, the treatment of immunotherapy and the use of hormone inhalation in accordance with IgE levels may be one of the ways of preventing and treating COPD.
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Corresponding Authors:
Zhu Guang-fa, E-mail:gfzhu6388@hotmail.com
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