多糖包被及其在失血性休克发展进程中的作用

doi:10.3969/j.issn.1002-1949.2018.03.022

Chinese Journal of Critical Care Medicine

2018, Vol. 38

Issue (3): 273-278 DOI: 10.3969/j.issn.1002-1949.2018.03.022

Glycocalyx and its role during hemorrhagic shock

Zhao Meng, Zhao Zi-Gang

Institute of Microcirculation, Hebei North University, Zhangjiakou 075000, China

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Abstract The glycocalyx is an important component of endothelial double barrier, has various physiological functions includes anti-inflammation and anti-coagulation, etc. Hemorrhagic shock induces the damage of glycocalyx, which plays important roles in the vascular hyper-permeability, excessive inflammation, and increased blood coagulation, and becomes one of mechanisms by which refractory hemorrhagic shock. The current article reviews the structure and function of glycocalyx and its role during hemorrhagic shock, thus, provides a novel approach for treatment of hemorrhagic shock basing on glycocalyx. 

Key words： Glycocalyx Hemorrhagic shock Capillary leak syndrome(CLS)

Received: 09 December 2017

Corresponding Authors: Zhao Zi-gang, E-mail: zzghyl@126.com

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Cite this article:

Zhao Meng,Zhao Zi-Gang. Glycocalyx and its role during hemorrhagic shock [J]. Chinese Journal of Critical Care Medicine, 2018, 38(3): 273-278.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2018.03.022 OR http://www.cnemergency.org.cn/EN/Y2018/V38/I3/273

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