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| Paraquat poisoning and AMPK signaling pathway |
| Wu Liao-zhang, Zhou Man-hong |
| Department of Emergency, Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China |
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Abstract The treatment of paraquat (PQ) poisoning is a worldwide problem.Studies have found that oxidative stress, inflammatory reaction and the formation of fibrosis play a very important role in PQ poisoning.AMP-activated protein kinase(AMPK), as an energy receptor, not only regulates energy balance, but also has antioxidant, anti-inflammatory and anti-fibrotic effects by regulating its upstream and downstream signals. Therefore, the role of this signaling pathway in PQ poisoning and treatment has attracted much attention in recent years.The author will review the relationship between AMPK signaling pathway and PQ poisoning.
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Corresponding Authors:
Zhou Man-hong, E-mail: 1067637135@qq.com
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