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| The application of procalcitonin and procalcitonin clearance in prognostic evaluation of sepsis |
| Zhang Yu-kun, Huo Shu-hua, Tian Ying-ping, Hu Jun-li, Chen Hui |
| Department of Emergency, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China |
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Abstract Objective To observe to the relationship between procalcitonin (PCT) and procalcitonin clearance (PCTc) and sepsis in ICU patients, and to explore the application value of PCT and PCTc in the prognosis of sepsis. Methods Patients with sepsis who met the inclusion requirements in the emergency ICU of our hospital from January 2017 to December 2018 were retrospectively analyzed, and their basic information, clinical data, PCT concentration on admission for 24 h and PCT concentration on the morning of the 3rd, 5th and 7th day were collected, and PCTc on each day was calculated.APACHEⅡscore was calculated according to the worst indicator on admission for 24 h.On the basis of 28 days the patients were divided into improvement group and deterioration group. The differences of PCT and PCTc between the two groups were compared to assess the value of each index for prognosis. Results There was no significant difference in PCT between the two groups on the 1st, 3rd and 5th day. On the 7th day, the PCT(ng/mL) of the deterioration group was higher than that of the improvement group,18.9(6.80,39.90)vs. 2.3 (1.30,14.75). On the 3rd,5th,7th day the PCTc(%) of the improvement group was higher than those of the deterioration group, on 3rd day 58(27-74)vs. 0.01(-2.68,0.46),on 5th day 86(70,92)vs. -0.82(-10.42,0.64),on 7th day 94(71,96)vs. 0.20(-4.30,0.70).In assessing prognosis, the three-day PCTc was similar to the APACHEⅡ. The five-day PCTc and the seven-day PCTc were superior to the APACHEⅡ(P<0.05). Conclusion The absolute value of PCT can not be directly used to evaluate the prognosis. The PCTc can evaluate the prognosis to some extent. In comparison, the seven-day PCTc has a better prognostic effect.
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Corresponding Authors:
Huo Shu-hua, E-mail： flower66699@126.com
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