|
|
|
|
|
| Treatment effect and safety analysis in early acute renal injury after coronary artery bypass grafting surgery by levosimendan combined with glycerol fructose |
| Hao Wen-bo， Wang yu， Jiang yun-fei, Han Zhen-dong |
| Department of Cardiology No.1, Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, China |
|
|
|
|
Abstract Objective Purpose to discuss the treatment effect and safety analysis in early acute renal injury after coronary artery bypass grafting surgery by Levosimendan combined with glycerol fructose. Methods Atotal of 126 cases of patients undergoing coronary artery bypass grafting were collected as study subjects from December 2012 to December 2016 in our hospital department of cardiothoracic surgery. By random number table method, they were divided into observation group and control group. There were 63 cases of patients in control group, all the patients were treated by levosimendan injection.There were 63 cases of patients in observation group, based on the treatment of control group. They were glycerol and fructose injection treatment. The heart and renal dysfunction and adverse reactions of the two groups before and after treatment were compared. Results All patients successfully completed coronary artery bypass grafting,there was statistical significance in the total effective rate of the patients with acute renal injury after operation (88.89% vs.69.84%, P<0.05).There was no significant difference in LVEF(%) and LVFS(%) between the two groups before treatment (P>0.05).After treatment, the improvement effect of LVEF and LVFS in observation group was significantly higher than control group (40.88±5.39 vs. 36.53±5.49，30.26±6.07 vs.24.34±7.59, P<0.05). There were no serious adverse reactions or complications occurred in both groups during treatment. Conclusion Levosimendan combined with glycerol fructose can effectively treat acute renal injury after coronary artery bypass grafting, can quickly and actively improve the patient′s renal function, can stop the progressive development of kidney damage, and safe, reliable, with the application and promotion of value.
|
|
|
|
Corresponding Authors:
Han zhen-dong， E-mail: 1472638412@qq.com
|
|
|
|
| ［1］张燕, 叶楠, 程虹, 等. 冠状动脉造影和非体外循环搭桥术间隔时间与急性肾损伤的关系［J］. 中华临床医师杂志（电子版）, 2013, 7(6):2332-2337.
［2］张宪芬, 高文根, 张殿宝,等. 冠脉搭桥术后急性肾损伤临床分析［J］. 中国心血管病研究, 2015, 13(5):460-463.
［3］Habib RH, Dimitrova KR, Badour SA, et al. CABG Versus PCI: Greater Benefit in Long-Term Outcomes With Multiple Arterial Bypass Grafting［J］. J Am Coll Cardiol, 2015, 66(13):1417-1427.
［4］李江涛, 许晨, 蒋晓峰, 等. 肌酐估测值对冠状动脉搭桥术后患者急性肾损伤的诊断价值［J］. 中国血液净化, 2010, 9(7):372-374.
［5］Barbara E. Effects of P-Selectin Antagonist Inclacumab inPatients Undergoing Coronary Artery Bypass Graft Surgery: SELECT-CABG Trial［J］. J Am Coll Cardiol, 2016, 67(3):344.
［6］黎莉, 通晴, 丁琳,等. 左西孟旦对冠状动脉搭桥患者术中血流动力学及心功能的支持作用［J］. 中国老年学杂志, 2016, 36(19):4741-4743.
［7］施乾坤, 章淬, 肖继来. 左西孟旦治疗冠脉搭桥术后低心排综合征并急性肾损伤20例临床评价［J］. 中国药业, 2016, 25(1):39-41.
［8］陈祖君, 裴锋博, 吴慧,等. 左西孟旦对重症冠状动脉旁路移植患者术后血流动力学的影响［J］. 中华胸心血管外科杂志, 2015, 31(5):297-299.
［9］李良, 张辉. 肾康注射液联合左西孟旦治疗冠状动脉搭桥术后早期急性肾损伤的疗效观察［J］. 现代药物与临床, 2017, 32(4):666-669.
［10］Goel K, Pack QR, Lahr B, et al. Cardiac rehabilitation is associated with reduced long-term mortality in patients undergoing combined heart valve and CABG surgery［J］. Eur J Prev Cardiol, 2015, 22(2):159-168.
［11］Zhang YJ, Iqbal J, van Klaveren D, et al. Smoking is associated with adverse clinical outcomes in patients undergoing revascularization with PCI or CABG: the SYNTAX trial at 5-year follow-up［J］. J Am Coll Cardiol, 2015, 65(11):1107-1115.
［12］易卫东, 李翠霞, 洪华,等. 甘油果糖联合小剂量甘露醇对颅脑损伤患者肾功能电解质的影响［J］. 中国临床实用医学, 2010, 4(6):140-142.
［13］孔昊, 王东信. 非体外循环下冠脉搭桥患者术前白蛋白水平与术后急性肾功能损伤的关系［J］. 实用医学杂志,2017, 33(6):938-942.
［14］袁彤. 甘露醇和甘油果糖治疗急性脑血管患者肾损害的分析［J］. 中外医疗, 2016, 35(1):131-133. |
|
|
|
Address: 1 North 2nd Street,
Zhongguancun, 
