|
|
|
|
|
The research progress of p53 in acute kidney injury |
Long Hong-ling, Xu Fang, Liao Xiao-hui |
Department of Nephrology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China |
|
|
Abstract Acute renal injury is a clinical syndrome caused by a variety of etiology, the incidence of acute renal injury is high, the prognosis is poor, and it is a serious threat to human life. The pathogenesis of acute renal injury is a hot research topic in recent years. p53 is one of the most important tumor suppressor factors in cells. In recent years, p53 has been found to play an important role in autophagy, cell metabolism, acute renal injury and post-injury repair. This article reviews the role of p53 in acute renal injury.
|
|
Corresponding Authors:
Liao Xiao-hui, E-mail: lxh@hospital.cqmu.edu.cn
|
|
|
|
[1]Fang Y, Teng J, Ding X. Acute kidney injury in China[J]. Hemodial Int, 2015, 19(1): 2-10.
[2]Kruiswijk F, Labuschagne CF, Vousden KH. p53 in survival, death and metabolic health: a lifeguard with a licence to kill[J]. Nat Rev Mol Cell Biol, 2015, 16(7): 393-405.
[3]Qu D, Jiang M, Huang D, et al. Synergistic effects of the enhancements to mitochondrial ROS, p53 activation and apoptosis generated by aspartame and potassium sorbate in HepG2 cells[J]. Molecules, 2019, 24(3). pii: e457.
[4]Saldana-Meyer R, Recillas-Targa F. Transcriptional and epigenetic regulation of the p53 tumor suppressor gene[J]. Epigenetics, 2011, 6(9):1068-1077.
[5]Kelly KJ, Plotkin Z, Vulgamott SL, et al. P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor[J]. J Am Soc Nephrol, 2003, 14(1): 128-138.
[6]Molitoris BA, Dagher PC, Sandoval RM, et al. siRNA targeted to p53 attenuates ischemic and cisplatin-induced acute kidney injury[J]. J Am Soc Nephrol, 2009, 20(8): 1754-1764.
[7]Ying Y, Kim J, Westphal SN, et al. Targeted deletion of p53 in the proximal tubule prevents ischemic renal injury[J]. J Am Soc Nephrol, 2014, 25(12): 2707-2716.
[8]Zhang D, Liu Y, Wei Q, et al. Tubular p53 regulates multiple genes to mediate AKI[J]. J Am Soc Nephrol, 2014, 25(10): 2278-2289.
[9]Zhou L, Fu P, Huang XR, et al. Activation of p53 promotes renal injury in acute aristolochic acid nephropathy[J]. J Am Soc Nephrol, 2010, 21(1): 31-41.
[10]Wei Q, Dong G, Yang T, et al. Activation and involvement of p53 in cisplatin-induced nephrotoxicity[J]. Am J Physiol Renal Physiol, 2007, 293(4): F1282-1291.
[11]Chen J, Wang J, Li H, et al. p53 activates miR-192-5p to mediate vancomycin induced AKI[J]. Sci Rep, 2016, 6: 38 868.
[12]Parzych KR, Klionsky DJ. An overview of autophagy: morphology, mechanism, and regulation[J]. Antioxid Redox Signa, 2014, 20(3): 460-473.
[13]Ko GJ, Bae SY, Hong YA, et al. Radiocontrast-induced nephropathy is attenuated by autophagy through regulation of apoptosis and inflammation[J]. Hum Exp Toxicol, 2016, 35(7): 724-736.
[14]Howell GM, Gomez H, Collage RD, et al. Augmenting autophagy to treat acute kidney injury during endotoxemia in mice[J]. PLoS One, 2013, 8(7): e69 520.
[15]Kaushal GP, Shah SV. Autophagy in acute kidney injury[J]. Kidney Int, 2016, 89(4): 779-791.
[16]Jing Z, Han W, Sui X, et al. Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers[J]. Cancer Lett, 2015, 356(2 Pt B): 332-338.
[17]Periyasamy-Thandavan S, Jiang M, Wei Q, et al. Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells[J]. Kidney Int, 2008, 74(5): 631-640.
[18]Xie SB, He XX, Yao SK. Matrine-induced autophagy regulated by p53 through AMP-activated protein kinase in human hepatoma cells[J]. Int J Oncol, 2015, 47(2): 517-526.
[19]Kenzelmann Broz D, Spano Mello S, Bieging KT, et al. Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses[J]. Genes Dev, 2013, 27(9): 1016-1031.
[20]Bensaad K, Cheung EC, Vousden KH. Modulation of intracellular ROS levels by TIGAR controls autophagy[J]. EMBO J, 2009, 28(19): 3015-3026.
[21]Tang C, Han H, Yan M, et al. PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury[J]. Autophagy, 2018, 14(5): 880-897.
[22]Zhao C, Chen Z, Xu X, et al. Pink1/Parkin-mediated mitophagy play a protective role in cisplatin induced renal tubular epithelial cells injury[J]. Exp Cell Res, 2017, 350(2): 390-397.
[23]Hoshino A, Mita Y, Okawa Y, et al. Cytosolic p53 inhibits parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart[J]. Nat Commun, 2013, 4: 2308.
[24]Goiran T, Duplan E, Rouland L, et al. Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation[J]. Cell Death Differ, 2018, 25(5): 873-884.
[25]Vaseva AV, Marchenko ND, Ji K, et al. p53 opens the mitochondrial permeability transition pore to trigger necrosis[J]. Cell, 2012, 149(7): 1536-1548.
[26]Hao J, Wei Q, Mei S, et al. Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6[J]. Kidney Int, 2017, 91(1): 106-118.
[27]Martin-Sanchez D, Ruiz-Andres O, Poveda J, et al. Ferroptosis, but not necroptosis, is important in nephrotoxic folic acid-induced AKI[J]. J Am Soc Nephrol, 2017, 28(1): 218-229.
[28]Martin-Sanchez D, Fontecha-Barriuso M, Carrasco S, et al. TWEAK and RIPK1 mediate a second wave of cell death during AKI[J]. Proc Natl Acad Sci U S A, 2018, 115(16): 4182-4187.
[29]Moonen L, D′Haese PC, Vervaet BA. Epithelial cell cycle behaviour in the Injured Kidney[J]. Int J Mol Sci, 2018, 19(7): e2038.
[30]Emlet DR, Shaw AD, Kellum JA. Sepsis-associated AKI: epithelial cell dysfunction[J]. Semin Nephrol, 2015, 35(1): 85-95.
[31]Aregger F, Uehlinger DE, Witowski J, et al. Identification of IGFBP-7 by urinary proteomics as a novel prognostic marker in early acute kidney injury[J]. Kidney Int, 2014, 85(4): 909-919.
[32]Pabla N, Gibson AA, Buege M, et al. Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions[J]. Proc Natl Acad Sci U S A, 2015, 112(16): 5231-5236.
[33]DiRocco DP, Bisi J, Roberts P, et al. CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury[J]. Am J Physiol Renal Physiol, 2014, 306(4): F379-388.
[34]Yang L, Besschetnova TY, Brooks CR, et al. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury[J]. Nat Med, 2010, 16(5): 535-543. |
|
|
|