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| The diagnostic value of serum Tenascin-C in patients with acute aortic dissection |
| Guo Tao, Zhou Yang, Chai Xiang-ping, Peng Wen, Cai Yu-zhong, Peng Zhen-yu, Yang Gui-fang |
| Department of Emergency, the Second Xiangya Hospital of Central South University, Changsha 410011, China |
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Abstract Objective To investigate the diagnosis value of serum Tenascin-C (TN-C) in patients with acute aortic dissection (AAD), and compare it with traditional biomarkers. Methods In this prospective study, 108 continuous patients with suspected AAD were enrolled, which included 48 AAD, 20 acute pulmonary embolism (APE), 20 acute myocardial infarction (AMI) and 20 non-cardiac chest pain (NCCP). Blood sample and clinic information in this patients were collected. Serum TN-C, sELAF, DD levels in these patients were measured by enzyme linked immunosorbent assay (ELISA). Binary logistic regression was performed to determine the independent risk factors of AAD. ROC curve analyzed the performance of each biomarker and compare it with combination of biomarkers in early diagnosis of AAD. Results Serum TN-C levels in patients with AAD was significantly higher than APE, AMI and NCCP group. The median of serum TN-C levels were 111.15 ng/mL, 49.55 ng/mL, 55.70 ng/mL, 15.70 ng/mL (P＜0.01), respectively. Binary logistic regression revealed that TN-C, DD and sELAF were independent risk factors for diagnosis of AAD. ROC curve analysis founded that the area under the curve of TN-C, DD and sELAF were 0.891, 0.785 and 0.797, respectively. Combination of TN-C and DD or sELAF, combination of all biomarkers was 0.919, 0.915 and 0.933. Further study confirmed that the area under the curve of combination of three biomarkers was superior to TN-C alone. And its sensitivity and specificity were 97.92% and 73.33%. Conclusion TN-C is a valuable marker for early diagnosis of AAD. Combination of TN-C, DD and sELAF can significantly improve the diagnosis performance in early diagnosis of AAD.
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Corresponding Authors:
Chai Xiang-ping, E-mail: chaixiangping@csu.edu.cn
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