颅脑损伤术后脑梗死患者D-二聚体和超敏C反应蛋白的表达及预后相关性研究

doi:10.3969/j.issn.1002-1949.2019.09.015

Chinese Journal of Critical Care Medicine

2019, Vol. 39

Issue (9): 878-881 DOI: 10.3969/j.issn.1002-1949.2019.09.015

Expression of D-dimer and high-sensitivity C reactive protein in patients with cerebral infarction after craniocerebral trauma and its prognostic significance

Liu Bo-xuan, Chen Cheng, Gong Jiu-mei, Li Dong-jing, Xiao Chun-wen, Xu Xu-dong

Department of Precision Medicine, Huaihua Second People′s Hospital, Huaihua 412000, China

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Abstract Objective To analyze the expression of D-dimer and high-sensitivity C reactive protein (hs-CRP) on the clinical prognosis of patients with posttraumatic cerebral infarction (PTCI). Methods A total of 53 PTCI patients were recruited from 2011 to 2017, and the disease severity was assessed by Glasgow coma scale (GCS). Levels of hs-CRP and D-dimer were detected and the relationship with patient′s condition and death rate were investigated. And 77 patients of traumatic brain injury with no secondary cerebral infarction were as control. Results The expression of D-dimer and hs-CRP in PTCI patients increased significantly with the severity of the cerebral infarction. The value of D-dimer and hs-CRP in PTCI patients were (7015.3±402.6)μg/L and (505.3±10.7)μg/L respectively on the 7th day after surgery, while the value was (3866.7±201.2)μg/L and (278.7±17.4)μg/L in the control group. There was significantly difference between the two groups (P<0.05). Logistic regression analysis indicated that the expression of D-dimer and hs-CRP had interdependency with PTCI (OR was 1.061 and 1.019, respectively). Conclusion Level of D-dimer and hs-CRP are the important marker to evaluate the PTCI. And both of them may serve as a potential marker to the progressive and diagnosis of PTCI. 

Key words： Posttraumatic cerebral infarction(PTCI) D-dimer High-sensitivity C reactive protein( hs-CRP)

About author:: Liu Bo-xuan, E-mail： luola9657@126.com

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	Liu Bo-xuan
	Chen Cheng
	Gong Jiu-mei
	Li Dong-jing
	Xiao Chun-wen
	Xu Xu-dong

Cite this article:

Liu Bo-xuan,Chen Cheng,Gong Jiu-mei, et al. Expression of D-dimer and high-sensitivity C reactive protein in patients with cerebral infarction after craniocerebral trauma and its prognostic significance[J]. Chinese Journal of Critical Care Medicine, 2019, 39(9): 878-881.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2019.09.015 OR http://www.cnemergency.org.cn/EN/Y2019/V39/I9/878

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