血清集聚蛋白C末端片段水平在老年心力衰竭并发肾损伤患者中的临床意义

doi:10.3969/j.issn.1002-1949.2019.07.004

Chinese Journal of Critical Care Medicine

2019, Vol. 39

Issue (7): 629-632 DOI: 10.3969/j.issn.1002-1949.2019.07.004

Elevated levels of C-terminal agrin fragment and its significance in elderly patients with heart failure complicated with renal injury

Wang De-guo, Zhao Chun-mei, Wang An-cai, Song Jun

Department of Geriatrics, Yijishan Hospital of Wannan Medical College, Wuhu 241001, China

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Abstract Objective To assess the levels of C-terminal agrin-fragment (CAF) and analyze its correlation with renal injury in elderly patients with heart failure. Methods A total of 180 elderly heart failure patients with NYHA class 3-4 who hospitalized into our hospital from December 2013 to December 2014 were enrolled. Based on estimate glomerular filtration rate (eGFR<60 mL·（min·1.73m2), patients with heart failure were divided into renal injury and non-kidney injury groups. Clinical characteristics, laboratory tests, and serum CAF levels were compared between the two groups. Results Among these heart failure patients, 71 cases were complicated with renal injury. Serum CAF level in the renal injury group was significantly higher than that in the non-kidney injury group（ng/L:975±369 vs. 712±350, P=0.028）. Correlation analysis showed that heart failure complicated with renal injury was significantly associated with serum CAF level (r=0.249, P=0.001). Even after adjusting for age, gender, serum creatinine, cystatin C and other factors, the increase of serum CAF is still the risk of kidney injury (OR=1.102, 95%CI1.008-1.118, P<0.045). ROC analysis showed that the AUC of CAF>760.7 ng/L for identified kidney injury was 0.690, with the predictive sensitivity of 0.842, and the specificity of 0.423. Conclusion Some patients with heart failure are complicated with renal injury, and the elevated serum CAF levels are correlated with renal function. Abnormally elevated serum CAF has an important clinical significance in identifying renal injury in heart failure patients.

Key words： Heart failure Renal injury C-terminal agrin fragment Cardiorenal syndrome

About author:: Wang De-guo, E-mail：wangdeguo@medmail.com.cn

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	Wang De-guo
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	Song Jun

Cite this article:

Wang De-guo,Zhao Chun-mei,Wang An-cai, et al. Elevated levels of C-terminal agrin fragment and its significance in elderly patients with heart failure complicated with renal injury[J]. Chinese Journal of Critical Care Medicine, 2019, 39(7): 629-632.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2019.07.004 OR http://www.cnemergency.org.cn/EN/Y2019/V39/I7/629

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