|
|
|
|
|
| Advancement in the application of vitamin C in sepsis |
| Wang Fei-fei, Zhu Xiao-ping, Ma Shao-lin |
| Department of Critical Care Medicine, Shanghai East Hospital, Tongji University of School Medicine, Shanghai 200120, China |
|
|
|
|
Abstract Sepsis severely threat human health which impaired the microcirculation, tissue hypoxia and multiple organ failure. In recent years, a growing body of research has shown that pathophysiological changes in patients with sepsis associated with oxidative stress. The effect of antioxidant supplementation with vitamin C for improving the condition of patients with sepsis with multiple effect, can improve the prognosis of patients. This article reviews the related researches of mechanism and the clinical applications of vitamin C in septic patients in order to timely implement an effective intervention measures for septic patients to improve survival rate.
|
|
Received: 28 May 2017
|
|
Corresponding Authors:
Ma Shao-lin, E-mail: m_slin@sina.com
|
|
|
|
| ［1］曾令勇, 何志兵. 二氯醋酸二异丙胺对脓毒症患者肝功能损害的治疗作用［J］. 华西医学, 2015, 30(2):275-278.
［2］Tyml K. Vitamin C and microvascular dysfunction in systemic inflammation［J］. Antioxidants, 2017, 6(3):1-11.
［3］Wilson JX. Evaluation of vitamin C for adjuvant sepsis therapy ［J］. Antioxid Redox Signal, 2013, 19(17):2129-2140.
［4］Rizzo AN, Dudek SM. Endothelial glycocalyx repair: building a wall to protect the lung during sepsis ［J］. Am J Respir Cell Mol Biol, 2017, 56(6):687-688.
［5］Stepien KM, Heaton R, Rankin S, et al. Evidence of oxidative stress and secondary mitochondrial dysfunction in metabolic and non-metabolic disorders ［J］. J Clin Med, 2017, 6(7):71.
［6］Bernal ME, Varon J, Acosta P, et al. Oxidative stress in critical care medicine ［J］. Int J Clin Pract, 2010, 64(11):1480-1488.
［7］Park DW, Zmijewski JW. Mitochondrial dysfunction and immune cell metabolism in sepsis ［J］. Infect Chemother, 2017, 49(1):10-21.
［8］Marik PE, Khangoora V, Rivera R, et al. Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study［J］. Chest, 2017, 151(6):1229-1238.
［9］Oudemans-van Straaten HM, Spoelstra-de Man AM, de Waard MC. Vitamin C revisited ［J］. Crit Care, 2014, 18(4):460.
［10］May JM, Harrison FE. Role of vitamin C in the function of the vascular endothelium ［J］. Antioxid Redox Signal, 2013, 19(17):2068-2083.
［11］May JM. Vitamin C transport and its role in the central nervous system ［J］. Subcell Biochem, 2012, 56:85-103.
［12］Fowler AA 3rd, Syed AA, Knowlson S, et al. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis ［J］. J Transl Med, 2014, 12:32.
［13］Schorah CJ, Downing C, Piripitsi A, et al. Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients ［J］. Am J Clin Nutr, 1996, 63(5):760-765.
［14］Pleiner J, Mittermayer F, Schaller G, et al. High doses of vitamin C reverse escherichia coli endotoxin-induced hyporeactivity to acetylcholine in the human forearm ［J］. Circulation, 2002, 106(12):1460-1464.
［15］De Grooth HM, Spoelstra-de Man AME, Oudemans-van Straaten HM. Early plasma vitamin C concentration, organ dysfunction and ICU mortality ［J］. Intensive Care Med, 2014, 40(1):S199-200.
［16］Berger MM，Oudemans-van Straaten HM. Vitamin C supplementation in the critically ill patient ［J］. Curr Opin Clin Nutr Metab Care, 2015, 18(2):193-201.
［17］Baines M, Shenkin A. Lack of effectiveness of short-term intravenous micronutrient nutrition in restoring plasma antioxidant status after surgery ［J］. Clin Nutr, 2002, 21(2):145-150.
［18］Armour J, Tyml K, Lidington D, et al. Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat ［J］. J Appl Physiol, 2001, 90(3):795-803.
［19］庞天舒，刘达人，曹利平，等. 脓毒症的抗氧化治疗进展 ［J］. 国际外科学杂志， 2013， 40(6):402-404.
［20］Mo SJ, Son EW, Rhee DK, et al. Modulation of TNF-alpha-induced ICAM-1 expression, NO and H2O2 production by alginate, allicin and ascorbic acid in human endothelial cells ［J］. Arch Pharm Res, 2003, 26(3):244-251.
［21］Wu F, Wilson JX. Peroxynitrite-dependent activation of protein phosphatase type 2A mediates microvascular endothelial barrier dysfunction ［J］. Cardiovasc Res, 2009, 81(1):38-45.
［22］May JM, Qu ZC. Nitric oxide mediates tightening of the endothelial barrier by ascorbic acid［J］. Biochem Biophys Res Commun, 2011, 404(2):701-705.
［23］Ohama T, Brautigan DL. Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A ［J］. J Biol Chem, 2010, 285(12):8711-8718.
［24］Zhou G, Kamenos G, Pendem S, et al. Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis ［J］. Am J Physiol Regul Integr Comp Physiol, 2012, 302(4):R409-416.
［25］Gaut JP, Belaaouaj A, Byun J, et al. Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation ［J］. Free Radic Biol Med, 2006, 40(9):1494-1501.
［26］鲍扬，李维勤，黎介涛. 腹腔感染后微生素A、E、C代谢障碍的防治 ［J］. 中华急诊医学杂志， 2006， 15(5):399-401.
［27］Fisher BJ, Seropian IM, Kraskauskas D, et al. Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury ［J］. Crit Care Med, 2011, 39(6):1454-1460.
［28］Blumental-Perry A, Bonfield TL. Editorial: Modulation of HMGB1 holds promise for managing sepsis immune paralysis ［J］. J Leukoc Biol, 2017, 101(6): 1273-1275.
［29］杨婉，张平安，韩瑞玲. 脓毒症休克患者血浆高迁移率族蛋白B1表达水平动态变化及临床意义［J］. 国际检验医学杂志, 2017 , 38 (4) :433-435,438.
［30］Kim SR, Ha YM, Kim YM, et al. Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals ［J］. Biochem Pharmacol, 2015, 95(4):279-289.
［31］吴田田，姚咏明. 脓毒症免疫紊乱及其临床意义［J］. 解放军医学杂志， 2017, 42(2):95-102.
［32］Jeong YJ, Kim JH, Hong JM, et al. Vitamin C treatment of mouse bone marrow-derived dendritic cells enhanced CD8(+) memory T cell production capacity of these cells in vivo ［J］. Immunobiology, 2014, 219(7):554-564.
［33］Gao YL, Lu B, Zhai JH, et al. The parenteral vitamin C improves sepsis and sepsis-induced multiple organ dysfunction syndrome via preventing cellular immunosuppression ［J］. Mediators Inflamm, 2017, 2017:4 024 672.
［34］Wagner SC, Markosian B, Ajili N, et al. Intravenous ascorbic acid as an adjuvant to interleukin-2 immunotherapy ［J］. J Transl Med, 2014, 12:127.
［35］Carr AC, Shaw GM, Fowler AA, et al. Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock ［J］. Crit Care, 2015, 19:418.
［36］May JM, Qu ZC, Nazarewicz R, et al. Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine ［J］. Brain Res Bull, 2013, 90:35-42.
［37］Zabet MH, Mohammadi M, Ramezani M, et al. Effect of high-dose Ascorbic acid on vasopressor′s requirement in septic shock ［J］. J Res Pharm Pract, 2016, 5(2):94-100.
［38］Padayatty SJ, Sun H, Wang Y, et al. Vitamin C pharmacokinetics: implications for oral and intravenous use ［J］. Ann Intern Med, 2004, 140(7):533-537.
［39］Long CL, Maull KI, Krishnan RS, et al. Ascorbic acid dynamics in the seriously ill and injured ［J］. J Surg Res, 2003, 109(2):144-148.
［40］Swarbreck SB, Secor D, Ellis CG, et al. Short-term effect of ascorbate on bacterial content, plasminogen activator inhibitor-1, and myeloperoxidase in septic mice ［J］. J Surg Res, 2014, 191(2):432-440.
［41］Thomas LD, Elinder CG, Tiselius HG, et al. Ascorbic acid supplements and kidney stone incidence among men: a prospective study ［J］. JAMA Intern Med, 2013, 173(5):386-388.
［42］Du J, Cullen JJ, Buettner GR. Ascorbic acid: chemistry, biology and the treatment of cancer ［J］. Biochim Biophys Acta, 2012, 1826(2):443-457.
［43］Padayatty SJ, Sun H, Wang Y, et al. Vitamin C pharmacokinetics: implications for oral and intravenous use ［J］. Ann Intern Med, 2004, 140(7):533-537.
［44］Muhlhofer A, Mrosek S, Schlegel B, et al. High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers ［J］. Eur J Clin Nutr, 2004, 58(8):1151-1158.
［45］Koekkoek WA, van Zanten AR. Antioxidant vitamins and trace elements in critical illness［J］. Nutr Clin Pract, 2016, 31(4):457-474.
［46］Carlson D, Maass DL, White DJ, et al. Antioxidant vitamin therapy alters sepsis-related apoptotic myocardial activity and inflammatory responses ［J］. Am J Physiol Heart Circ Physiol, 2006, 291(6):H2779-2789.
［47］Howe KP, Clochesy JM, Goldstein LS, et al. Mechanical ventilation antioxidant trial ［J］. Am J Crit Care, 2015, 24(5):440-445.
［48］Kim JY, Lee SM. Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis ［J］. Eur J Pharmacol, 2006, 534(1-3):202-209. |
|
|
|
Address: 1 North 2nd Street,
Zhongguancun, 
