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| The diagnostic value of inflammatory markers and D-dimer level in secondary infection of acute pancreatitis |
| Liu Si-yuan, Zhang Hong |
| Department of Emergency Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China |
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Abstract Objective To investigate the diagnostic value of procalcitonin(PCT), C-reactive protein(CRP), white blood cell(WBC) and D-dimer in the assessment of secondary infection in patients with acute pancreatitis(AP). Methods A total of 123 cases with pancreatitis were selected by retrospective method. These patients were divided into the infected group（n=53） and the uninfected group（n=70） based on with or without secondary abdominal infection within a month after admission, then the infection group（n=37） was divided into local infection group（n=16） and severe infection group according to the severity of infection. These indicators were compared between the infected and uninfected group, local infection group and severe infection group. Results Significant difference of PCT, CRP and D-dimer were found between the infected and uninfected groups with ［2.43 (1.21-6.21)］ ng/mLvs.［0.32 (0.10-0.93)］ ng/mL, (158.03±132.62) mg/L vs. (79.26±80.10) mg/L and (7.28±4.56) μg/mL vs. (2.07±1.86) μg/mL (P＜0.05). The difference of WBC between the two groups was not significant with (14.59±4.99)×109/L vs. (12.73±5.42)×109/L(P=0.053) respectively. The difference of PCT was significant between local infection and severe group with (3.04±3.36) ng/mL vs. (15.02±14.83) ng/mL (P＜0.05). The difference of CRP, D-dimer and WBC between the two groups was not significant with (156.83±142.94) mg/L vs. (160.80±109.17) mg/L, (7.20±4.00) μg/mL vs. (7.46±5.81) μg/L，and (14.39±4.67)×109/L vs. (15.07±5.79)×109/L(P>0.05). The diagnostic value of D-dimer level is better than PCT, CRP level. The area under the ROC was 0.917 with sensitivity 90.6%，specificity 78.6%. Conclusion PCT, CRP and D-dimer level in blood can be used as indicators for diagnosis of secondary infectin in patients with pancreatitis; and D-dimer is better than using PCT and CRP after admission, but the PCT level can diagnose severity of infection.
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Corresponding Authors:
Zhang Hong, E-mail: zhanghong20070703@ 163.com
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