非肝病性高血氨在重症患者中值得关注

doi:10.3969/j.issn.1002-1949.2019.04.003

Chinese Journal of Critical Care Medicine

2019, Vol. 39

Issue (4): 313-315 DOI: 10.3969/j.issn.1002-1949.2019.04.003

Attention should be paid to non-hepatic hyperammonemia in severe patients

Yao Zhi-peng, Wang Hong-liang

Intensive Care Unit, the Second Hospital Affliated Harbin Medical University, Harbin 150080, China

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Abstract As the main metabolite of amino acid in vivo, blood ammonia plays an important role in the process of material metabolism and biotransformation. Current studies tend to focus on the theory of high blood ammonia and ammonia poisoning caused by liver diseases, but the reasons for the increase of blood ammonia caused by non-liver diseases and the effects of high blood ammonia on other organ functions have been neglected. At present, it is believed that the increase of blood ammonia caused by other causes in patients without hepatic disease (acute liver failure or chronic liver disease) is referred to as non-hepatic hyperammonemia (NHH). However, at present, NHH has not been paid much attention by the clinicians. In this paper, the pathophysiological mechanism, clinical significance and the relationship between blood ammonia and disease in severe patients with NHH are discussed in the hope of that it will be helpful to clinical diagnosis, assessment and treatment of related diseases.

Key words： Non-hepatic hyperammonemia (NHH) Metabolism of amino acid Severe patients Blood ammonia detection

Corresponding Authors: Wang Hong-liang, E-mail: icuwanghongliang@163.com

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Yao Zhi-peng,Wang Hong-liang. Attention should be paid to non-hepatic hyperammonemia in severe patients[J]. Chinese Journal of Critical Care Medicine, 2019, 39(4): 313-315.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2019.04.003 OR http://www.cnemergency.org.cn/EN/Y2019/V39/I4/313

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