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| Research progress of mild therapeutic hypothermia in acute myocardial infarction |
| Deng Wei, Li Yi-ling, Yu Shu-chun |
| Department of Anesthesiology, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China |
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Abstract As a hotspot of current research, mild therapeutic hypothermia (MTH) is considered as a new strategy to reduce myocardial ischemia/reperfusion injury after reperfusion therapeutics, and its cardioprotective effect has been confirmed in many ischemic experimental models (cardiac arrest, stroke and organ preservation). However, randomized clinical controlled trials have failed to demonstrate that MTH can reduce myocardial infarct size in patients with acute myocardial infarction (AMI). Nevertheless, the negative results of clinical trials cannot ignore the cardioprotective effects of MTH. This apparent discrepancy between experimental data and clinical data may be related to the window of MTH application. This article will give a brief overview of the basic principles of MTH and the possible mechanisms of previous studies, and introduce the effective methods of MTH clinical application in patients with AMI, lessons from current clinical trials and future development directions.
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Corresponding Authors:
Yu Shu-chun, E-mail: yscdoc@hotmail.com
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