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| The protective effect of rosiglitazone on paraquat-induced acute kidney injury in rats |
| Sang Zhen-zhen,Guo Jin-ping, Jia Chun-mei, Li Yong |
| Department of Emergency, Cangzhou Central Hospital, Cangzhou 061000, China |
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Abstract Objective: Toinvestigate the protective effects of rosiglitazone on paraquat(PQ)-inducedacute kidney injury(AKI).Methods: 90 healthy male Sprague-Dawley rats(250～300 g)were randomly divided into 3 groups: control group(n=10),1 mL 0.9% sodium chloride solution was administered intraperitoneally; model group, PQ was administered intraperitoneally at the dose of 20 mg/kg; rosiglitazone group,rosiglitazone was administered immediately after PQ administration once a day. The concentration of TNF-α, IL-1β, iNOS and HMGB-1 in serum were measured by ELISA at 4,24,36,72 hour after PQ exposure. At the same time points, the levels of serum Cr and BUN were alsodetected. Pathological changes of kidney tissues were observed by transmission electron microscopy. Results: The levels of Cr, BUN, TNF-α, IL-1β, iNOS and HMGB-1 in serum of rosiglitazone group were significantly lower than those inmodel group(P＜0.05). Rosiglitazone also lessened the kidneyhistological changes. Conclusion: Rosiglitazonecan inhibit the levels of TNF-α, IL-1β, iNOS and HMGB-1 in serum, thus modify the inflammatory response and provided protective effects against acute kidney injury induced by PQ poisoning in rats.
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Received: 28 April 2017
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Corresponding Authors:
Li Yong,E-mail:sangzhenzhen1985@163.com
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