甘油三酯/高密度脂蛋白胆固醇的比值在急性缺血性脑卒中预后价值的研究

doi:10.3969/j.issn.1002-1949.2017.10.012

Chinese Journal of Critical Care Medicine

2017, Vol. 37

Issue (10): 923-928 DOI: 10.3969/j.issn.1002-1949.2017.10.012

Triglyceride to high-density lipoprotein cholesterol ratio predicts worse outcomes after acute ischemic stroke

Sun Cai-zhi, Deng Qi-wen, Zhang Zheng,He Xiao-wei

Department of Emergency, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China

Abstract
Figure/Table
References (14)
Related Citation (15)

Download: PDF (3224 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: The effect of triglyceride(TG)to high-density lipoprotein cholesterol(HDL-C) ratio (TG/HDL-C)on clinical outcomes of acute ischemic stroke(AIS)patients is unclear. This study sought to determine whether the TG/HDL-C in AIS patients is associated with worse outcomes. Methods: AIS patients were enrolled in this study. TG, total cholesterol(TC), HDL-C, and low-density lipoprotein cholesterol(LDL-C)were collected on admission. We defined 2 endpoints according to the modified Rankin scale(mRS)score at 3 months after symptom onset(excellent outcome, mRS 0～1 and death, mRS 6). Results: Higher TG, non-HDL-C and TG/HDL-C were strongly associated with the 2 endpoints after adjustments: excellent［odds ratio（OR）=1.39, OR=1.89 and OR=2.34, respectively)and death(OR=0.59, OR=0.29 and OR=0.26)］. According to the receiver operator characteristic(ROC)analysis, the best discriminating factor was a TG/HDL-C≥0.87 for excellent outcomes［area under the ROC curve（AUC）0.596， sensitivity 73.3%， specificity 42.7%］and non-death(AUC 0.674， sensitivity 67.8%， specificity 60.6%). Patients with a TG/HDL-C<0.87 had a 2.94-fold increased risk of death compared with patients with a TG/HDL-C ≥0.87. Conclusion: A lower TG/HDL-C is independently associated with death and worse outcome at 3 months in AIS.

Received: 18 February 2017

Corresponding Authors: He Xiao-wei, E-mail: 188645866@qq.com

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Sun Cai-zhi
	Deng Qi-wen
	Zhang Zheng
	He Xiao-wei

Cite this article:

Sun Cai-zhi,Deng Qi-wen,Zhang Zheng, et al. Triglyceride to high-density lipoprotein cholesterol ratio predicts worse outcomes after acute ischemic stroke[J]. Chinese Journal of Critical Care Medicine, 2017, 37(10): 923-928.

URL:

http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2017.10.012 OR http://www.cnemergency.org.cn/EN/Y2017/V37/I10/923

［1］岳伟，吴昊，石志鸿，等.血浆同型半胱氨酸水平与急性缺血性脑卒中患者的卒中复发及死亡关系的研究［J］.中华神经医学杂志, 2016, 15(7):654-659. ［2］Hankey GJ. Long-term outcome after ischaemic stroke/transient ischaemic attack［J］. Cerebrovasc Dis, 2003, 16(Suppl 1):14-19. ［3］Markaki I, Nilsson U, Kostulas K, et al. High cholesterol levels are associated with improved long-term survival after acute ischemic stroke［J］. J Stroke Cerebrovasc Dis, 2014, 23(1):e47-53. ［4］Pan SL, Lien IN, Chen TH. Is higher serum total cholesterol level associated with better long-term functional outcomes after noncardioembolic ischemic stroke［J］. Arch Phys Med Rehabil, 2010, 91(6):913-918. ［5］Choi KH, Park MS, Kim JT, et al. Serum triglyceride level is an important predictor of early prognosis in patients with acute ischemic stroke［J］. J Neurol Sci, 2012, 319(1-2):111-116. ［6］Gonzalez-Chavez A, Simental-Mendia LE, Elizondo-Argueta S. Elevated triglycerides/HDL-cholesterol ratio associated with insulin resistance［J］. Cir Cir, 2011, 79(2):126-131. ［7］Millan J, Pinto X, Munoz A, et al. Lipoprotein ratios: physiological significance and clinical usefulness in cardiovascular prevention［J］. Vasc Health Risk Manag, 2009, 5:757-765. ［8］Bittner V, Johnson BD, Zineh I, et al. The triglyceride/high-density lipoprotein cholesterol ratio predicts all-cause mortality in women with suspected myocardial ischemia: a report from the Women′s Ischemia Syndrome Evaluation(WISE)［J］. Am Heart J, 2009, 157(3):548-555. ［9］Sonmez A, Yilmaz MI, Saglam M, et al. The role of plasma triglyceride/high-density lipoprotein cholesterol ratio to predict cardiovascular outcomes in chronic kidney disease［J］. Lipids Health Dis, 2015, 14:29.〖ZK）〗 ［10］Choi KH, Park MS, Kim JT, et al. Serum triglyceride level is an important predictor of early prognosis in patients with acute ischemic stroke［J］. J Neurol Sci, 2012, 319(1-2):111-116. ［11］Pikija S, Trkulja V, Juvan L, et al. Higher on-admission serum triglycerides predict less severe disability and lower all-cause mortality after acute ischemic stroke［J］. J Stroke Cerebrovasc Dis, 2013, 22(7):e15-24. ［12］Li W, Liu M, Wu B, et al. Serum lipid levels and 3-month prognosis in Chinese patients with acute stroke［J］. Adv Ther, 2008, 25(4):329-341. ［13］Ryu WS, Lee SH, Kim CK, et al. Effects of low serum triglyceride on stroke mortality: a prospective follow-up study［J］. Atherosclerosis, 2010, 212(1):299-304. ［14］Simundic AM, Nikolac N, Topic E, et al. Are serum lipids measured on stroke admission prognostic ［J］. Clin Chem Lab Med, 2008, 46(8):1163-1167.