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| Peripheral level of sST2 and NT-proBNP in predicting the recent clinical prognosis for patients after cardiopulmonary resuscitation |
| Yu Hai-xia, Han Xue, Liu Hai-yang, Wu Li-zhu, Zhang Wen-bo, Liu Yue-hui |
| Department of Emergency, Chengde City Center Hospital, Chengde 067000, China |
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Abstract Objective To explore the relationship between the level of growth soluble ST2 (sST2), NT-proBNP in peripheral blood and the recent clinical prognosis of cardiopulmonary resuscitation (CPR). Methods A total of 160 patients with sudden cardiac arrest who received CPR were divided into three groups. The patients whose sST2 levels are less than 200 μg/L assigned into Group A．Those whose sST2 levels at the time of 48-72 h after CPR are higher than the time of 0 h and 24 h after CPR assigned into Group B, and those whose sST2 levels at the time of 48-72 h after CPR are lower than the time of 0 h and 24 h after CPR assigned into Group C. Serum NT-proBNP, LVEDD, LVEF of three groups at different time points were detected. The patients were followed-up for 6 months to record mortality. Results sST2 and NT-proBNP showed interaction (F=14.875, P=0 .001). At the same time, LVEDD and LVEF changed with the level of sST2 and NT-proBNP. The mortality of sST2 high expression group and NT-proBNP high expression group were higher than that of low expression group (χ2=5.096, P<0.05). Survival analysis showed, 6 months survival rate of group B was significantly lower than that of group A (χ2 = 13.476, P=0.001) and group C (χ2 = 7.347, P=0.008), there was no statistical difference between group A and group C (χ2 = 2.385, P=0.086). Conclusion Serum sST2, NT-proBNP detection can well predict the recent clinical outcomes of patients with CPR．
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Corresponding Authors:
Han Xue, E-mail: hanxuecd@163.com
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| ［1］Breidthardt T, Balmelli C, Twerenbold R, et al. Heart failure therapy-induced early ST2 changes may offer long-term therapy guidance ［J］. J Card Fail, 2015, 19(12):821-828.
［2］Friedl W, Mair J, Thomas S, et al. Relationship between natriuretic peptides and hemodynamics in patients with heart failure at rest and after ergometric exercise［J］. Clin Chim Acta, 2014, 281 (1-2):121-126.
［3］Dieplinger B, Egger M, Haltmayer M, et al. Increased soluble ST2 predicts long term mortality in patients with stable coronary artery disease:results from the Ludwigshafen risk and cardiovascular health study［J］.Clin Chem, 2014, 60(3):530-540.
［4］张文斌, 唐其柱, 李金, 等．半乳糖凝集素-３在心力衰竭中的研究进展［Ｊ］．国际心血管病杂志， 2015, 42(5):320-322.
［5］Schmitz J, Owyang A, Oldham E, et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines［J］. Immunity, 2005, 23(5):479-490.
［6］Sanada S, Hakuno D, Higgins LJ, et al. IL-33 and ST2 comprise a critical biomechanically induced and cardoprotective signaling system［J］. J Clin Invest, 2007, 117(6):1538-1549.
［7］Januzzi JL Jr, Rehman S, Mueller T, et al. Importance of biomarkers for long-term mortality prediction in acutely dyspneic patients［J］. Clin Chem, 2013, 56(12):1814-1821.
［8］Socrates T, de Filippi C, Reichlin T, et al. Interleukin family member ST2 and mortality in acute dyspnoea［J］. J Intern Med, 2010, 268(5):493-500.
［9］Tsuruda T, Boerrigter G, Huntley BK, et al.Brain natriuretic peptide is produced in cardiac fibroblasts and induces matris metalloproteinases［J］. Cir Res, 2016, 91(12):1127-1134.
［10］曹志民, 于海侠, 檀立端, 等.心脏骤停患者心肺复苏成功后利钠肽水平变化与预后关系的研究［J］. 中国循环杂志， 2015， 30(9):859-862.
［11］Bettencourt P, Ferreira A,Dias P, et al. Evaluation of brain natriuretic peptide in the diagnosis of heart failure［J］. Cardiology, 2000, 93(1-2):19-25. |
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