应激性高血糖及氧化应激产物水平对急性心肌梗死患者预后的评估价值

doi:10.3969/j.issn.1002-1949.2019.01.012

Chinese Journal of Critical Care Medicine

2019, Vol. 39

Issue (1): 57-60 DOI: 10.3969/j.issn.1002-1949.2019.01.012

Evaluation on prognosis of patients with acute myocardial infarction by stress hyperglycemia and levels of oxidative stress products

Tang Li-ying, Bai Yu-zhi, Wang Jing, Ru Jing, Zhao Xia, An Yun

Department of Geriatrics, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100043, China

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Abstract Objective To investigate the evaluation value on prognosis of patients with acute myocardial infarction (AMI) by stress hyperglycemia and levels of oxidative stress products. Methods 160 patients with AMI were selected as group A, and were divided into group A1 (stress hyperglycemia group, FBG≥7.0 mmol/L) and group A2 (non-stress hyperglycemia group, FBG<7.0 mmol/L) by the blood glucose results. Another 50 volunteers were selected as group B. The levels of blood glucose and oxidative stress indicators were measured in two groups, including glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA). Rates of infection, adverse prognostic events such as cardiovascular events and death were compared in group A by follow-up. Results In 160 patients with AMI, the incidence of stress hyperglycemia was 35.0%. The serum levels of GSH-Px, CAT and SOD in the group A1 and A2 were lower than those in group B, and the MDA levels were higher than those in group B (t=5.17~9.05, P＜0.05 or P＜0.01). The serum levels of GSH-Px ［(451.72±82.60)U/L vs. (624.53±96.05)U/L］, CAT［(10.92±2.07)U/L vs. (14.35±2.81)U/L］ and SOD［(50.32±8.12)μU/L vs. (63.07±7.53)μU/L］ in group A1 were lower than those in group A2, and the levels of MDA［(8.17±1.01)μmol/L vs. (5.72±0.80)μmol/L］ were higher than that in group A2 (t=4.17~5.03, P＜0.05). Serum FBG was negatively correlated with GSH-Px, CAT, and SOD levels in group A (rGSH-Px=-0.46,rCAT=-0.89, rSOD=-0.62, P＜0.05), and positively correlated with MDA levels in group A (rMDA=0.47, P＜0.05). The incidence of infection (21.43% vs. 9.62%) and death (23.21% vs. 8.65%), severe arrhythmia (30.36% vs. 14.42%), cardiogenic shock (25.00% vs. 12.50%), heart failure (30.36% vs. 15.38%) and other cardiovascular events (25.00% vs. 12.50%) in group A1 were higher than those in group A2 (χ2=4.05~6.51, P＜0.05). Conclusion Stress hyperglycemia and oxidative stress may participate in the occurrence and development of AMI. The combined detection of both may serve as an index to predict the recent prognosis of AMI patients. Stress hyperglycemia and high oxidative stress state may predict poor prognosis of AMI patients. 

Key words： Acute myocardial infarction Stress hyperglycemia Oxidative stress Prognosis

Corresponding Authors: Wang Jing, E-mail: bjtlytt@sohu.com

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	Tang Li-ying
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Cite this article:

Tang Li-ying,Bai Yu-zhi,Wang Jing, et al. Evaluation on prognosis of patients with acute myocardial infarction by stress hyperglycemia and levels of oxidative stress products[J]. Chinese Journal of Critical Care Medicine, 2019, 39(1): 57-60.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2019.01.012 OR http://www.cnemergency.org.cn/EN/Y2019/V39/I1/57

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