血清PCT CRP及IL-6对老年重型脑外伤患者肺部感染的预测价值

doi:10.3969/j.issn.1002-1949.2019.01.004

Chinese Journal of Critical Care Medicine

2019, Vol. 39

Issue (1): 20-24 DOI: 10.3969/j.issn.1002-1949.2019.01.004

Predictive value of serum PCT, CRP and IL-6 on lung infection in elderly patients with severe brain injury

Xiao Hua, Zhuo Fen, Huang Juan-juan, Cai Yue-hong

Department of Clinical Laboratory, Third People′s Hospital of Hainan Province, Sanya 572000, China

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Abstract Objective To investigate the predictive value of serum procalcitonin (PCT), C- reactive protein (CRP) and interleukin-6 (IL-6) on lung infection in elderly patients with severe brain injury. Methods One hundred and seventy-two cases of elderly severe brain trauma treated in our hospital from January 2015 to December 2017. They were divided into infection group (81 cases) and non-infection group (91 cases) according to whether they had pulmonary infection. The changes of serum PCT, CRP and IL-6 levels in two groups on the first, third, fifth day after admission were compared. The predictive value of serum PCT, CRP and IL-6 levels in each time point for pulmonary infection was analyzed by ROC curve. Results The levels of serum PCT, CRP and IL-6 in the infected group were significantly higher than those in the non-infected group on third day and fifth day［PCT (ng/mL): 0.97±0.65 vs. 0.62±0.28, 2.41±1.26 vs. 0.48±0.17; CRP (mg/L): 88.63±15.41 vs. 74.50±12.28, 92.48±18.74 vs. 62.38±9.51; IL-6 (ng/L): 85.62±22.37 vs. 64.38±16.50, 94.26±28.50 vs. 57.30±12.48, all P<0.05］. The levels of serum PCT, CRP and IL-6 on the third day and fifth day of infection group were significantly higher than those on the first day［PCT (ng/mL): 0.97±0.65 and 2.41±1.26 vs. 0.60±0.31; CRP (mg/L): 88.63±15.41 and 92.48±18.74 vs. 67.24±10.25; IL-6 (ng/L): 85.62±22.37 and 94.26±28.50 vs. 54.83±12.16, all P<0.05］. The ROC curve showed that PCT, CRP and IL-6 on the third day combined prediction of pulmonary infection in elderly patients with severe brain injury of AUC (95%CI) with 0.904(0.845-0.966) was significantly higher than PCT d3 ［0.826 (0.768-0.887), CRP d3［0.805(0.748-0.865) and IL-6 d3 ［0.773 (0.715-0.835), the sensitivity and the specificity were 90.6% and 85.2%. Conclusion It is of great value to combined the third day PCT, CRP and IL-6 to predict lung infection in elderly patients with severe brain injury.

Key words： Severe brain trauma Procalcitonin (PCT) C- reactive protein (CRP) Interleukin-6 (IL-6) Lung infection Predictive value

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Cite this article:

Xiao Hua,Zhuo Fen,Huang Juan-juan, et al. Predictive value of serum PCT, CRP and IL-6 on lung infection in elderly patients with severe brain injury[J]. Chinese Journal of Critical Care Medicine, 2019, 39(1): 20-24.

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http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949.2019.01.004 OR http://www.cnemergency.org.cn/EN/Y2019/V39/I1/20

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