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| Effect observation of vitamin D combined with low dose glucocorticoid in the treatment of children with severe sepsis |
| Wei Hai-yan, Zhu Xiao-xin, Qi Gong-jian, Jiang Zhen, Wang Ming-guang |
| Department of Intensive Care Medicine, Xuzhou Children′s Hospital, Xuzhou 221000, China |
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Abstract Objective： To explore the clinical effect of vitamin D combined with low dose glucocorticoid in the treatment of children with severe sepsis. Methods： 136 children with severe sepsis were randomly divided into group A (conventional treatment, 45 cases), group B (routine treatment + low dose glucocorticoid, 54 cases) and group C (routine treatment + low dose of glucocorticoid and vitamin D, 37 cases), there were no significant difference among general data of the three groups (P＞0.05). Inflammatory infection index, PRISMⅢ score, PICU time, 28-day mortality and adverse reaction were compared among the three groups. Results： The levels of PCT and lactate of the group B and the group C after the treatment of 3 d, 7 d and 14 d were significantly lower than those in the group A (P＜0.05), but there was no significant difference among the three groups in CRP (P＞0.05). The PRISMⅢ score and PICU time of the group B and the group C were significantly lower than those of group A (P＜0.05). The 28-day mortality of the group B was lower than that of the group A, but there was no significant difference (P＞0.05), and the 28-day mortality of group C was significantly lower than that of group A and B (P＜0.05). Adverse reactions were of no significant difference (P＞0.05) among the three groups. Conclusion： The effect of low dose glucocorticoid adjuvant treatment of children with severe sepsis is good; it can improve the control of inflammatory markers and prognosis. Based on this, combined with vitamin D can reduce mortality.
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Received: 28 August 2017
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Corresponding Authors:
Wang Ming-guang,E-mail:wangmingxz@126.com
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