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| An analysis about the separation of plasma renin activity and aldosterone in patients with cardiopulmonary resuscitation |
| Zhu Li, Huang Jia, Yuan Qi-song, Zhou Hou-rong |
| Guizhou Medical University, Guiyang 550004, China |
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Abstract Objective To investigate the effect of separation of plasma renin activity and aldo⁃ sterone on return of spontaneous circulation（ROSC）in patients with cardiopulmonary resuscitation （CPR）. Method Thirty patients whose physical examinations were normal were randomly divided into group N; a total of 60 patients with sudden cardiac arrest who were treated with CPR were divided into two groups according to the effect of CPR, 28 patients with restoration of spontaneous circulation were group S, and 32 patients without restoration of spontaneous circulation were group U, at the Guizhou Province People's Hospital from January 2015 to December 2015. Peripheral venous blood of patients with CA 30 minites after CPR was collected, in order to test the plasma renin activity, aldosterone, serum potassium and sodium concentration and to compare each index between different groups. Results ① Compared to group N, plasma renin activity and aldosterone were obviously increased in group S and group U; and plasma renin activity and aldosterone in group U were higher than group S; the difference was statistically significant（P＜0.05）. ②The proportion of the separation of plasma renin activity andaldosterone in group S was lower than that in group U; the rate of ROSC in the group without separation of aldosterone was higher than the group with separation of aldosterone（2=4.63, P＜0.05）; and the level of serum potassium concentration in group with separation of aldosterone was higher than that in group with⁃ out separation of aldosterone（P＜0.01）; the level of plasma sodium concentration in group without sepa⁃ ration of aldosterone was lower than group with separation of aldosterone（P＜0.01）. Conclusion The phenomenon of the separation of renin activity and aldosterone exists in the patients who are treated with cardiopulmonary resuscitation, and the separation of plasma renin activity and aldosterone might induce hyponatremia and hyperkalemia, which is the disadvantage of cardiopulmonary resuscitation.
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Received: 04 August 2016
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Corresponding Authors:
Zhou Hou-rong, E-mail: zhr1974@163.com
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Zhongguancun, 