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| Clinical study of the changes of serum calcium-independent phospholipase A2 of wasp stings patients |
| Yang Jing-ning, Xiao Min, Yang Xian-yi, Sun Yu-wen, Chen Li-dong, Sun Yu-hui |
| Department of Emergency Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China |
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Abstract Objective To explore the changes and manifestations of serum calcium-indepen⁃ dent phospholipase A2（iPLA2）of wasp stings patients. Methods According to the laboratory examina⁃ tions, 34 wasp stings patients were divided into two groups: non-hemolytic group and hemolytic group. Serum of patients was isolated for preparation. Another 10 samples of healthy persons were included in the normal control group. On the basis of laboratory examination and clinical indications, the incidence of multiple organ dysfunction syndrome（MODS）was compared between non-hemolytic group and hemo⁃ lytic group. The serum levels of iPLA2, prostaglandin E2（PGE2）and thromboxane A2（TXA2）were de⁃ terminated by enzyme-linked immunosorbent assay（ELISA）. Finally, we compared the difference be⁃tween each group and analyzed the results with statistical methods. Results The proportion of MODS in patients with hemolytic group was significantly higher than that in non-hemolytic group（16/19 vs 5/ 15, P＜0.01）. The serum TXA2 of wasp stings patients was significantly higher than that in normal con⁃ trol group（P＜0.01）. Serum TXA2 in hemolytic group was higher than that in non-hemolytic group, but there was no significant difference between the two groups（P＞0.05）. Serum PGE2 in hemolytic group was significantly higher than that in non-hemolytic group（P＜0.01）. Serum iPLA2 in hemolytic group was significantly higher than that in non-hemolytic group and in normal control group（P＜0.01）. Serum iPLA2 level in wasp stings patients was positively correlated with the serum level of PGE2（r = 0.867, P =0.000）, and was also positively correlated with the serum level of TXA2（r = 0.543, P =0.004）. Conclusion Hemolysis is an important factor to cause MODS in wasp stings patients. The levels of serum iPLA2 increase significantly in wasp stings patients with hemolysis, suggesting that iPLA2 may be in⁃ volved in the occurrence and development of MODS in wasp stings patients. Dynamic monitoring of iPLA2 levels can assess the patient's condition, and guide the treatment of wasp stings patients, and help to judge the prognosis of patients.
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Received: 07 April 2016
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Corresponding Authors:
Xiao Min, E-mail: 446737603@qq.com
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