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| Research advances on the protection of therapeutic hypothermia against ST-segment elevation myocardial infarction |
| Wang Yong-sheng, Wang Lian-sheng |
| Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China |
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Abstract Early and successful restoration of myocardial perfusion is the most effective strategy to reduce infarct size and improve clinical outcomes in patients with acute myocardial infarction (AMI). But, reperfusion itself causes myocardial damage by ischemia/reperfusion injury as well. Data of experiments have shown that therapeutic hypothermia (TH) 32～34 ℃ could attenuate the reperfusion injury, prevent no-flow and improve ventricular remodeling in AMI models. However, inconsistent with those animal experiments, most clinical trials did not attain the same beneficial effects from TH in patients with AMI. Most recent meta-analysis reported that the benefit of TH still be observed in large infarct patients cooled rapidly before reperfusion. Novel strategies, including local induction of myocardium hypothermia and pre-hospital cooling, might be more beneficial in future.
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Received: 16 February 2017
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Corresponding Authors:
Wang Lian-sheng, E-mail:dryswang@njmu.edu.cn
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