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| Role of angiotensin-converting enzyme in shock-induced multiple organ injury |
| Su Kun, Xue Jun, Zhao Zi-gang, Niu Chun-yu |
| Institute of Microcirculation, Hebei North University, Zhangjiakou 075000, China |
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Abstract Angiotensin-converting enzyme (ACE) is an important component of renin-angiotensin system, and is associated with pathogenesis of multiple diseases. Various shocks induce excessive and uncontrolled inflammatory response, abnormal hemodynamics, intestine barrier injury and vascular hyper-permeability, which are important factors of multiple organ injury and death. The expressions of ACE, angiotensin Ⅱ (AngⅡ), and Ang Ⅱ type 1 receptor (AT1R) are increased in different organs during the various severe pathological process of endotoxic shock, hemorrhagic shock, ischemia-reperfusion injury, and burn shock. Inhibition of ACE-Ang Ⅱ-AT1R expressions plays a positive role in alleviating organ injury. The present article reviews the role of ACE in shock-induced multiple organ injury, therefore, provides a novel approach for treatment of shock through ACE.
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Received: 22 February 2017
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Corresponding Authors:
Zhao Zi-gang, E- mail: zzghyl@126.comNiu Chun-yu, E- mail: ncylxf@126.com
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