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Abstract Objective To explore the effect of phentolamine on blood lactic acid in patients with severe sepsis trends，as well as its influence on prognosis. Methods Using random number table， 55 patients with severe sepsis were divided into research group and the control group. The patients of both groups received conventional treatment following the SSC 2012 guide，except the patients in re⁃ search group were additionally given phentolamine injection. Before and 6，12，24，48，72 h after treat⁃ ment，the APACHE Ⅱ was respectively calculated，and the blood lactic acid，lactic acid clearance were also recorded and compared between two groups. ICU stay，acute renal failure need dialysis rate，me⁃ chanical ventilation time and the mortality of 28 days were also recorded in the two groups. Results Af⁃ ter treatment，APACHE Ⅱ score in research group was significantly lower than that in the control group （P＜0.05 or P＜0.01）. 12，24，48，72 h after treatment，the levels of blood lactic acid，lactic acid clear⁃ ance in research group improved better than that of control group; the difference has statistical signifi⁃ cance（P＜0.05 or P＜0.01）. Especially the 6 h lactate clearance in research group increased signifi⁃ cantly compared with control group（27.23±2.16 vs. 13.92±2.96，t＝8.322，P＜0.05）. ICU stay，acute renal failure need dialysis rate，mechanical ventilation time and the mortality of 28 days were all less than those of the control group，with statistical significance（P＜0.05 or P＜0.01）. Conclusion Com⁃ bined use of phentolamine can significantly improve the early blood lactic acid in patients with severesepsis and changing trends of the blood perfusion of microcirculation，increase of survival rate and quali⁃ ty of life of the patients with sepsis
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Received: 04 January 2016
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| About author:: YANG Wei，E-mail: yanggang20@126.com |
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Address: 1 North 2nd Street,
Zhongguancun, 
