miR-20a-5p对脓毒症患者急性肾损伤的早期诊断价值

doi:10.3969/j.issn.1002-1949201810007

Chinese Journal of Critical Care Medicine

2018, Vol. 38

Issue (10): 863-868 DOI: 10.3969/j.issn.1002-1949201810007

The early diagnostic value of miR-20a-5p on acute kidney injury in patients with sepsis

Li Da-yong, Dai Yao, Liu Guan-lan, Guo Ning， Tong Guo-xiang

Department of Critical Care Medicine, First Hospital of Changsha, Changsha 410005, China

Abstract
Figure/Table
References (19)
Related Citation (15)

Download: PDF (837 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To screen peripheral blood miRNAs related with acute kidney injury (AKI) in patients with sepsis; and to investigate the early diagnostic value of miRNAs on sepsis-AKI. Methods 82 patients with sepsis in our hospital were selected from September 2016 to January 2018 and divided into patients with sepsis combined with AKI (sepsis-AKI group, n=43) and patients without AKI group (sepsis group, n=39).Serum miRNA expression profiles were determined in blood samples from sepsis patients (after admission of 3 d) and sepsis-AKI patients (on diagnosis day or before 1 d). The levels of plasma miRNAs, biochemistry indexes, APACHEⅡ scores and qSOFA scores were detected and compared between the two groups. Results ①There was statistical difference of the baseline values of liver and kidney function indexes, APACHEⅡ scores and qSOFA scores between sepsis group (after admission of 3 d) and sepsis-AKI group(on diagnosis day) (P<0.05). ②The glomerlar filtration rate (GFR) of sepsis-AKI patients before diagnosis of 1 d were lower than sepsis patients without AKI (after admission of 3d) (P<0.05). ③The serum miR-20a-5p expression levelsin peripheral blood of sepsis-AKI patients before diagnosis of 1d were higher than sepsis patients without AKI (after admission of 3 d) (P<0.05). ④The high miR-20a-5p expression was an independent risk factor of AKI in sepsis patients (P<0.05). ⑤The AUC of ROC curve of miR-20a-5p was 0.923. Conclusion It suggested that miR-20a-5p is a sensitive predictor of acute kidney injury in patients with sepsis. 

Key words： Sepsis Acute kidney injury (AKI) miRNAs Early diagnosis

About author:: Li Da-yong, E-mail: xie258036@163.com

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Li Da-yong
	Dai Yao
	Liu Guan-lan
	Guo Ning
	Tong Guo-xiang

Cite this article:

Li Da-yong,Dai Yao,Liu Guan-lan, et al. The early diagnostic value of miR-20a-5p on acute kidney injury in patients with sepsis[J]. Chinese Journal of Critical Care Medicine, 2018, 38(10): 863-868.

URL:

http://www.cnemergency.org.cn/EN/10.3969/j.issn.1002-1949201810007 OR http://www.cnemergency.org.cn/EN/Y2018/V38/I10/863

［1］徐大民, 杨莉. 脓毒症相关急性肾损伤［J］. 中国实用内科杂志, 2016, 36 (6): 441-444. ［2］王瑶, 王洪亮. 急性肾损伤相关生物标志物研究现状［J］. 中国急救医学, 2018, 38(2): 108–110. ［3］朱桂军, 胡振杰. 急性肾损伤定义及诊断标准的昨天、今天与明天［J］. 中国急救医学, 2018, 38(2): 114–117. ［4］Zhou J, Chen H, Fan Y. Systematic analysis of the expression profile of non-coding RNAs involved in ischemia/reperfusion-induced acute kidney injury in mice using RNA sequencing ［J］. Oncotarget, 2017, 8(59):100196-100215. ［5］中华医学会重症医学分会. 中国严重脓毒症/脓毒性休克治疗指南（2014）［J］. 中华内科杂志, 2015, 54(6):557-581. ［6］Palevsky PM, Liu KD, Brophy PD, et al. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury［J］. Am J Kidney Dis, 2013, 61(5): 649-672. ［7］Karthikeyan B, Sharma RK. Management of acute kidney injury in sepsis［J］. Clinical Queries Nephrology, 2016, 5(1): 16-20. ［8］Chung KK, Stewart IJ, Gisler C, et al. The Acute Kidney Injury Network (AKIN) criteria applied in burns［J］. J Burn Care Res, 2012, 33(4):483-490. ［9］Skube SJ, Katz SA, Chipman JG, et al. Acute Kidney injury and Sepsis［J］. Surg Infect (Larchmt), 2018, 19(2):216-224. ［10］Rodríguez E, Arias-Cabrales C, Bermejo S, et al. Impact of Recurrent Acute Kidney injury on Patient Outcomes［J］. Kidney Blood Press Res, 2018, 43(1):34-44. ［11］Hellou E, Bahouth Z, Sabo E, et al. The impact of comorbidities, sex and age on the occurrence of acute kidney injury among patients undergoing nephron-sparing surgery［J］. Ther Adv Urol, 2018, 10(3):103-108. ［12］Mohamed MA, Hamid KA. How an Elevated Creatinine Level Can Deter the Diagnosis of Acute Aortic Dissection［J］. Cureus, 2018, 10(1):e2057. ［13］罗旭颖, 周建新, 席修明. 急性肾损伤的诊断:肌酐还是尿量［J］. 中华重症医学电子杂志, 2017, 32(1):9-13. ［14］王寅, 王蓓莉, 郭玮, 等. 肾小球滤过率计算公式的发展和比较［J］. 检验医学, 2015, 30(7): 668-673. ［15］Bjornstad P, Karger AB, Maahs DM. Measured GFR in Routine Clinical Practice-The Promise of Dried Blood Spots［J］. Adv Chronic Kidney Dis, 2018, 25(1):76-83. ［16］Wang Q, Ma J, Jiang Z, et al. Identification of microRNAs as diagnostic biomarkers for acute myocardial infarction in Asian populations: A systematic review and meta- analysis［J］. Medicine (Baltimore), 2017, 96(24): e7173. ［17］Xu T, Wu J, Han P, et al. Circular RNA expression profiles and features in human tissues: a study using RNA-seq data［J］. BMC Genomics, 2017, 18(Suppl 6):680. ［18］王勤熙, 姚见儿, 顾国浩. microRNAs的定量分析技术及其应用［J］. 临床检验杂志, 2012, 30(9):650-652. ［19］Ichii O, Horino T. MicroRNAs associated with the development of kidney diseases in humans and animals［J］. J Toxicol Pathol, 2018, 31(1):23-34.