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| The diagnostic value of NLR, PLR and PCT in children with strangulated intestinal obstruction |
| Luo Yan, Liu Bin |
| Department of Pediatrics, the First Affiliated Hospital of Southwest Medical University, Luzhou 646000, China |
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Abstract Objective We investigated the value of diagnosis of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and procalcitonin to predict early strangulated bowel obstruction in children, providing references for clinical work. Methods 76 cases of intestinal obstruction in children were included in our hospital from March 2015 to March 2018, including 46 cases of simple intestinal obstruction (simple group) and 30 cases of strangulated intestinal obstruction (strangulation group); the strangulation group was divided into ischemic group (n=13) and necrotic group (n=17), furtherly. All subjects were studied the levels of peripheral blood NLR, PLR and PCT levels 12 hours before operation. Results The values of serum NLR, PLR, and PCT in children with preoperative strangulated intestinal obstruction were significantly higher than those in children with simple intestinal obstruction. There were also statistically significant differences between two subgroups (intestinal ischemia and intestinal necrosis) in the strangulation group, values in the intestinal necrosis group were significantly higher than it in the ischemia group. A Pearson correlation analysis was used to find a moderate positive correlation between NLR and PLR (r=0.462, P＜0.05), and NLR, PLR and PCT showed low positive correlations (r=0.287, r=0.232, both P＜0.05). The diagnostic value of PCT was the highest value in the diagnosis of strangulated intestinal obstruction by single index, and its AUC, specificity and accuracy were 0.807, 78.91% and 77.80%, respectively. We found that the diagnostic value of the combined detection of the three indicators was better than the single or two indicators when combined detection with multiple inflammatory indicators, and the AUC, specificity and accuracy were 0.888, 95.65% and 85.20%, respectively. Conclusion Our study demonstrates that multiple inflammatory indexes NLR, PLR and PCT can be used as effective indicators for the diagnosis of stenotic intestinal obstruction in children. Combined detection of multiple indicators can improve the diagnostic efficacy of children with stenotic intestinal obstruction.
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