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| Brain protective effect and its mechanism of gangliosides in intracerebral hemorrhage rats |
| Ye Xiao-feng, Zheng Jian-ming, Lin Miao-chun, Ye Ming-yan, You Ping-di |
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Abstract Objective To observe the brain protective effect and its mechanism of gangliosides in intracerebral hemorrhage rats, and to explore the new approach in treatment of cerebral hemorrhage. Methods The 185 healthy Sprague Dawley (SD) rats were randomly selected and divided into shamed-operation group (A group), intracerebral hemorrhage group (B group), ICH gangliosides therapy. Rats were observed by neurological deficits and executed at each point, and brain water content, iNOS and ICAM-1 in rats′ brain of intracerebral hemorrhage model group were analyzed. Results ①After intracerebral hemorrhage happened in rats, neurological deficits reached peak at 24 h time point, and brain water content reached peak at 72 h time point. Neurological deficit and brain water content in group B showed significant difference with group A (P<0.05). In comparison with B group, neurological deficits and brain water content of group C, D and E were significantly reduced (P<0.05). ②After intracerebral hemorrhage happened in rats, the expression of iNOS and ICAM-1 reached peak at 72 h time point. In comparison with B group, the expression levels of iNOS and ICAM-1 of group C, D and E were significantly reduced (P<0.05); also, the selected dose in the experiment, 30 mg/kg showed better function than 15 mg/kg and 30 mg/kg (P<0.05). Conclusion Gangliosides may reduce the brain water content and improve the neurologic deficits of intracerebral hemorrhage. Gangliosides can reduce iNOS and ICAM-1 expression, which may be the possible mechanism of its decreased brain edema effect.
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