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| Serum MIP-1α level before and after PCI in patients with STEMI and IGT and acarbose′ intervention value |
| Qi Feng-jun, Dong Zhi, Zhao Xue-sen, Teng Hai-jiao, Lin Ji-hong, Xie Li-ying, Yang Hong-chao |
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Abstract Objective To explore the serum MIP-1α level before and after PCI in patients with STEMI and IGT and acarbose′ intervention value. Methods 160 STEMI patients undergoing PCI were selected as group A, and were divided into group A1 (with IGT) and group A2 (without IGT), and patients in group A1 were randomly divided into group A1a and group A1b, and 30 healthy volunteers were selected as group B. Patients in group A were all given standard PCI surgery, and patients in group A1a were given treatment of acarbose in addition for 6 months. On timepoint before PCI (T0), 24 h after PCI (T1), 6 months after PCI (T2) in group A, and on the day of medical examination in group B, their serum MIP-1α level were detected by ELISA. On timepoint of T0 in group A1 and group A2, they were all given echocardiography to understand left ventricular structure and function. Results The proportion of patients with STEMI and IGT was 71.25%. At T0, serum MIP-1α level in group A was significantly higher than that in group B (t=7.37, P＜0.01), also group A1 ′s serum MIP-1α level was higher than that in group A2 (t=4.63, P＜0.05). At T1, serum MIP-1α level were all increased in group A (t=3.65~4.77, P＜0.05), and group A1 ′s level was higher than that in group A2 (t=5.21,P＜0.05). At T2, serum MIP-1α level were all decreased in group A1a, A1b, A1, A2 and A (t=6.13~7.62, P＜0.01), and group A1 ′s level was lower than that in group A2 (t=4.06, P＜0.05). At T2, LVD and LVMI were all decreased, and LVEF were increased in group A 1aand group A1 (t=3.67~6.21, P＜0.05 or P＜0.01), LVMI was decreased and LVEF was increased in group A1b(tLVMI=3.53, tLVEF=3.85, P＜0.05), yet LVD and LVMI in group A1a were all lower than that in group A1b, and LVEF was higher than that in group A1b(t=3.40~4.12, P＜0.05). Conclusion Serum MIP-1α level in patients with STEMI and IGT are significantly higher than those in healthy person, showing a transient increase after PCI and a gradually decrease thereafter. Intervention with acarbose therapy on patients with STEMI and IGT, can further reduce serum MIP-1α level, relieve inflammatory reaction, and improve the structure and function of left ventricle, so it has certain reference value for its clinical diagnosis and treatment.
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Received: 17 May 2017
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