徐定华，马青变. 心脏骤停后脑微循环障碍的机制及其干预措施研究进展[J]. 中国急救医学, 2018, 38(8): 732-735.
Xu Ding-hua， Ma Qing-bian. Progress in the mechanism and intervention of cerebral microcirculatory disturbance after cardiac arrest. Chinese Journal of Critical Care Medicine, 2018, 38(8): 732-735.
［1］Mozaffarian D, Benjamin EJ, Go AS, et al. Heart disease and stroke statistics-2015 update:a report from the AmericanHeart Association［J］. Circulation, 2015, 131(4):e29-322.
［2］Centers for Disease Control and Prevention. 2013 Cardiac Arrest Registry to Enhance Survival (CARES) National Summary Report. https:// mycares.net/sitepages/uploads/2014/2013CARES National Summary Report.〖JP〗 Accessed July 15, 2014.
［3］Li L, Poloyac SM, Waltkins SC, et al. Cerebral microcirculatory alterations and the no-reflow phenomenon in vivo after experimental pediatric cardiacarrest［J］. Cereb Blood Flow Metab, 2017, 1:271678X17744717.
［4］Ames A3rd, Wright RL, Kowada M, et al. Cerebral ischemia. II. The no-reflow phenomenon［J］. Am J Pathol, 1968, 52(2):437-453.
［5］Hall CN, Reynell C, Gesslein B, et al. Capillary pericytes regulate cerebral blood flow in health and disease［J］. Nature, 2014, 508(7494): 55-60.
［6］Hill RA, Tong L, Yuan P, et al. Regional blood flow in the normal and ischemic brain is controlled by arteriolar smooth muscle cell contractility and not by capillary pericytes［J］. Neuron, 2015, 87(1): 95-110.
［7］Sitina M， Turek Z， Parízková R, et al. In Situ Assessment of the Brain Microcirculation in mechanically-ventilated rabbits using sidestream dark-field (SDF) imaging［J］. Physiol Res, 2011, 60(1):75-81.
［8］Krupicková P, Mormanová Z, Boucek T, et al. Microvascular perfusion in cardiac arrest: a review ofmicrocirculatory imaging studies［J］. Perfusion, 2018, 33(1):8-15.
［9］Iordanova B, Li L, Clark RSB, et al. Alterations in Cerebral Blood Flow after Resuscitation from Cardiac Arrest［J］. Front Pediatr, 2017, 5:174.
［10］Liu R, Li X, Hu CL, et al. The changes of brain water diffusion and blood flow on diffusion-weighted and perfusion-weighted imaging in a canine model of cardiac arrest［J］. Resuscitation, 2012, 83(5):645-651.
［11］Ristagno G, Tang W, Sun S, et al. Cerebral cortical microvascular flow during and following cardiopulmonary resuscitation after short duration of cardiac arrest［J］. Resuscitation, 2008, 77(2): 229-234.
［12］Fries M, Tang W, Chang YT, et al. Microvascular blood flow during cardiopulmonary resuscitation is predictiveof outcome［J］. Resuscitation, 2006, 71(2):248-253.
［13］Krupicková P, Mlcek M, Huptych M, et al. Microcirculatory blood flow during cardiac arrest and cardiopulmonary resusitation does not correlate with global hemodynamics:an experimental study［J］. Transl Med, 2016, 14(1):163.
［14］Xanthos T, Chalkias A. Therapeutic hypothermia: Focus on microcirculation［J］. Resuscitation, 2014, 85(5):583-584.
［15］Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest［J］. N Engl J Med, 2002, 346(8):549-556.
［16］Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia［J］. N Engl J Med, 2002, 346(8):557-563.
［17］Donadello K, Favory R, Salgado-Ribeiro D, et al. Sublingual and muscular microcirculatory alterations after cardiac arrest: a pilot study［J］. Resuscitation, 2011, 82(6):690-695.
［18］He X, Su F, Taccone FS, et al. Cardiovascular and microvascular responses to mild hypothermia in an ovine model［J］. Resuscitation, 2012, 83(6):760-766.
［19］Gong P, Zhao S, Wang J, et al. Mild hypothermia preserves cerebral cortex microcirculation after resuscitation in a rat model of cardiac arrest［J］. Resuscitation, 2015, 97:109-114.
［20］Chun-Lin H, Jie W, Xiao-Xing L, et al. Effects of therapeutic hypothermia on coagulopathy and microcirculation after cardiopulmonary resuscitation in rabbits［J］. Am J Emerg Med, 2011, 29(9):1103-1110.
［21］Omar YG, Massey M, Andersen LW, et al. Sublingual microcirculation is impaired in post-cardiac arrest patients［J］. Resuscitation, 2013, 84(12):1717-1722.
［22］Wu J, Yuan W, Li J, et al. Effects of Mild Hypothermia on Cerebral Large and Small Microvessels Blood Flow in a Porcine Model of CardiacArrest［J］. Neurocrit Care, 2017, 27(2):297-303.
［23］Chen Y, Wang L, Zhang Y, et al. The Effect of Therapeutic Mild Hypothermia on Brain Microvascular Endothelial Cells During Ischemia-Reperfusion Injury［J］. Neurocrit Care, 2018, 28(3):379-387.
［24］Gong P, Zhao S, Wang J, et al. Mild hypothermia preserves cerebral cortex microcirculation after resuscitation in a rat model of cardiac arrest［J］. Resuscitation, 2015, 97:109-114.
［25］Wada T.Coagulofibrinolytic Changes in Patients with Post-cardiac Arrest Syndrome［J］. Front Med(Lausanne), 2017, 4:156.
［26］Fischer M, Bttiger BW, Popov-Cenic S, et al. Thrombolysis using plasminogen activator and heparin reduces cerebral no-reflow after resuscitation from cardiac arrest: an experimental study in the cat［J］. Intensive Care Med, 1996, 22(11):1214-1223.
［27］Yin Q, Liu B, Wu C, et al. Effects of Shen-Fu injection on coagulation-fibrinolysis disorders in a porcine model of cardiac arrest［J］. Am J Emerg Med, 2016, 34(3):469-476.
［28］Teschendorf P, Padosch SA, Del Valle Y Fuentes D, et al. Effects of activated protein C on post cardiac arrest microcirculation: an in vivo microscopy study［J］. Resuscitation, 2009, 80(8):940-945.
［29］Chun-Lin H, Jie W, Xiao-Xing Li, et al. Effects of therapeutic hypothermia on coagulopathy and microcirculation after cardiopulmonary resuscitation in rabbits［J］. Am J Emerg Med, 2011, 29(9):1103-1110.
［30］Nielsen AK, Jeppesen AN, Kirkegaard H, et al. Changes in coagulation during therapeutic hypothermia in cardiac arrestpatients［J］. Resuscitation, 2016, 98(1):85-90.
［31］Jacob M, Hassager C, Bro-Jeppesen J, et al. The effect of targeted temperature management on coagulation parameters and bleeding events after out-of-hospital cardiac arrest of presumed cardiac cause［J］. Resuscitation, 2015, 96(2):260-267.
