Lingo-1及其相关传导通路在神经系统修复中的研究进展

doi:10.3969/j.issn.1002-1949.2018.07.0016

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摘要富含亮氨酸重复序列和免疫球蛋白结构域的Nogo受体作用蛋白-1（Lingo-1）在神经元与少突胶质细胞修复、神经突延长、轴突再生等过程中，通过NgR/p75/Lingo-1或NgR/TROY/Lingo-1、WNK1、Myt1与Myt1l等通路发挥明确的负性调节作用，阻断Lingo-1及其通路可促进损伤的中枢神经系统再生，提示Lingo-1有可能成为治疗神经精神系统疾病的新靶点。

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	王天双
	肖刚
	李林
	张俭
	张德新
	陆莹

关键词 ：富含亮氨酸重复序列和免疫球蛋白结构域的Nogo受体作用蛋白-1（Lingo-1）, 中枢神经系统损伤, 神经再生, 传导通路

基金资助:黑龙江省自然科学基金面上项目（H201422）

通讯作者: 陆莹（1971-），女，博士，副教授，急诊科副主任，副主任医师，硕士生导师，E-mail：lyholly@163.com。

作者简介: 王天双（1991-），女，硕士，E-mail:alice.z.wang@foxmail.com。

引用本文:

王天双，肖刚，李林，张俭，张德新，陆莹. Lingo-1及其相关传导通路在神经系统修复中的研究进展[J]. 中国急救医学, 2018, 38(7): 636-640.
Wang Tian-shuang, Xiao Gang, Li Lin, Zhang Jian, Zhang De-xin, Lu Ying. Research progresses on Lingo-1 and its related conductive pathway for nervous system repair. Chinese Journal of Critical Care Medicine, 2018, 38(7): 636-640.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2018.07.0016 或 http://www.cnemergency.org.cn/CN/Y2018/V38/I7/636

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