血清尿酸水平对癫痫与晕厥的鉴别诊断价值

doi:10.3969/j.issn.1002-1949.2018.05.007

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摘要目的探讨血清尿酸水平对癫痫与晕厥的鉴别诊断价值。方法选取2012-11~2017-04在北京积水潭医院神经内科急诊就诊并诊断为癫痫或晕厥的患者，其中癫痫患者106例，晕厥患者102例，发病12 h以内抽静脉血，用尿酸酶法测定血清尿酸水平。结果癫痫组患者的血清尿酸水平显著高于晕厥组［（529.28±202.35）μmol/L vs.（306.84±76.02）μmol/L，t=10.417,P＜0.01］。癫痫组患者血清尿酸水平升高的比例显著高于晕厥组（71.70% vs.8.82%，χ2=85.035，P＜0.01）。癫痫组患者血清尿酸水平与年龄呈负相关（r=-0.302，P=0.002）；晕厥组患者血清尿酸水平与年龄无相关性（P=0.653）。对25例尿酸升高的癫痫患者进行随访，22例（88%）患者在癫痫发作后3 d内血清尿酸水平降至正常，其余3例（12%）血清尿酸水平较前也有显著下降。〖HTH〗结论〓〖HTSS〗血清尿酸水平对癫痫与晕厥的鉴别有一定的临床指导价值。

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	姜明
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关键词 ：尿酸, 癫痫, 晕厥

通讯作者: 胡洪涛（1973-），男，博士，神经内科主任，E-mail： hhtsd@163.com。

作者简介: 姜明（1982-），女，博士，主治医师，E-mail： mjiang1122@163.com。

引用本文:

姜明，胡洪涛，闫欣，闫立荣. 血清尿酸水平对癫痫与晕厥的鉴别诊断价值[J]. 中国急救医学, 2018, 38(5): 403-.
Jiang Ming, Hu Hong-tao, Yan Xin, Yan Li-rong. Value of serum uric acid level in the differential diagnosis of epilepsy and syncope. Chinese Journal of Critical Care Medicine, 2018, 38(5): 403-.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2018.05.007 或 http://www.cnemergency.org.cn/CN/Y2018/V38/I5/403

［1］Paulson GW.Elevation of serum uric acid levels in patients withseizures［J］. Ohio State Med J， 1978， 74（5）：292-293. ［2］Castro-Gago M，Rodríguez-Segade S，Camia Darriba F，et al.Cerebrospinal fluid purine metabolites after complex febrile convulsions［J］.Childs Nerv Syst， 1996， 12（6）：315-317. ［3］刘凤英, 蔡学坤, 赵旦,等. 癫痫与血清尿酸水平变化［J］. 中国医学创新， 2014， 11(12):11-13. ［4］Rodrigues Tda R, Sternick EB, Moreira Mda C. Epilepsy or syncope an analysis of 55 consecutive patients with loss of conseiousness， convulsions， falls， and no EEG abnormalities［J］．Pacing Clin Electrophysiol， 2010， 33(7)：804-813． ［5］Josephson CB，Rahey S，Sadler RM．Neurocardiogenie syncope：frequency and consequences of its misdiagnosis as epilepsy［J］．Can J Neurol Sci， 2007， 34(2)：221-224． ［6］Layton ME, Samson FE, Pazdernik TL.Kainic acid causes redox changes in cerebral cortex extracellular fluid: NMDA receptor activity increases ascorbic acid whereas seizure activity increases uric acid［J］. Neuropharmacology, 1998, 37（2）:149-157. ［7］Thyrion L,Raedt R, Portelli J, et al. Uric acid is released in the brain during seizure activity and increases severity of seizures in a mouse model for acute limbic seizures［J］. Exp Neurol, 2016, 277:244-251. ［8］Hamed SA， Abdellah MM， El-Melegy N. Blood levels of trace elements, electrolytes, and oxidative stress/antioxidant systems in epileptic patients［J］. J Pharmacol Sci, 2004, 96（4）:465-473. ［9］Togha M, Akhondzadeh S, Motamedi M,et al. Allopurinol as adjunctive therapy in intractable epilepsy: a double-blind and placebo-controlled trial［J］. Arch Med Res， 2007, 38（3）:313-316. ［10］Grosso S， Longini M， Rodriguez A， et al. Oxidative stress in children affected by epileptic encephalopathies［J］. J Neurol Sci， 2011， 300（1-2）：103-106. ［11］Vezzani A, Balosso S, Maroso M, et al.ICE/caspase 1 inhibitors and IL-1beta receptor antagonists as potential therapeutics in epilepsy［J］. Curr Opin Investig Drugs, 2010, 11（1）:43-50. ［12］Vezzani A, Maroso M, Balosso S, et al. IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures［J］. Brain Behav Immun, 2011, 25（7）:1281-1289. ［13］Meng XF, Tan L, Tan MS,et al. Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdale kindling-induced status epilepticus［J］. J Neuroinflammation, 2014, 11:212.