p53在急性肾损伤中的研究进展

doi:10.3969/j.issn.1002-1949.2019.10.018

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摘要急性肾损伤（AKI）是一种由多种病因引起的临床综合征，发病率高、预后差，严重威胁人类生命健康，其发病机制为近年来的研究热点。p53是目前研究中最为重要的肿瘤抑制因子之一，在细胞自噬、细胞代谢、AKI及损伤后修复中具有重要作用。本文就p53在AKI中的研究进展进行综述。

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	龙泓伶
	徐昉
	廖晓辉

关键词 ： p53, 急性肾损伤（AKI）, 自噬, 细胞凋亡

基金资助:国家自然科学基金面上项目（81873604）;重庆市留学人员创业创新支持计划（cx2018038）

通讯作者: 廖晓辉（1978-），男，博士，主任医师，副教授，硕士生导师，E-mail：lxh@hospital.cqmu.edu.cn

作者简介: 龙泓伶（1994-），女，硕士研究生，E-mail：358473416@qq.com。

引用本文:

龙泓伶,徐昉,廖晓辉. p53在急性肾损伤中的研究进展[J]. 中国急救医学, 2019, 39(10): 1007-1010.
Long Hong-ling, Xu Fang, Liao Xiao-hui. The research progress of p53 in acute kidney injury. Chinese Journal of Critical Care Medicine, 2019, 39(10): 1007-1010.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2019.10.018 或 http://www.cnemergency.org.cn/CN/Y2019/V39/I10/1007

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