长链非编码RNA在脓毒症性心肌病中的潜在作用与意义

doi:doi:10.3969/j.issn.1002-1949.08.021

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摘要脓毒症（sepsis）是指宿主对感染的反应失调引起危及生命的器官功能障碍。其病死率居高不下，且以脓毒症性心肌病（sepsis induced cardiomyopathy，SIC）引起的病死率升高最为明显，是急危重症医学面临的巨大挑战。脓毒症期间“炎性瀑布”与“基因风暴”密切相关。长链非编码RNA（long chain non-coding RNA，lncRNAs）通过调控炎症反应和免疫调节过程，对脓毒症及SIC产生重要影响。本文就近年来lncRNAs在SIC中的炎性调控机制进行综述。

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	张玲
	张海丹
	赵婧
	肖丹阳
	李培武

关键词 ：脓毒症, 脓毒症性心肌病（SIC）, 长链非编码RNA(lncRNAs), 炎性调控

基金资助:兰州市人才创新创业项目（2016-RC-52）

通讯作者: 李培武（1966-），男，博士，教授，主任医师，E-mail：wuzi360@126.com。

作者简介: 张玲(1992-)，女，硕土研究生，E-mail：lzhang17@lzu.edu.cn。

引用本文:

张玲，张海丹，赵婧，肖丹阳，李培武. 长链非编码RNA在脓毒症性心肌病中的潜在作用与意义[J]. 中国急救医学, 2019, 39(8): 809-812.
Zhang Ling, Zhang Hai-dan, Zhao Jing, Xiao Dan-yang, Li Pei-wu. The potential role and significance of longchain non-coding RNA in sepsis induced cardiomyopathy. Chinese Journal of Critical Care Medicine, 2019, 39(8): 809-812.

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http://www.cnemergency.org.cn/CN/doi:10.3969/j.issn.1002-1949.08.021 或 http://www.cnemergency.org.cn/CN/Y2019/V39/I8/809

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