血清miR-302b在老年急性心肌梗死中的表达及其临床意义

doi:10.3969/j.issn.1002-1949.2019.07.014

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摘要目的探讨血清miR-302b在老年急性心肌梗死（AMI）患者中的表达及其临床意义。方法选取本院收治的138例老年AMI患者和65例老年体检者，比较两组血清miR-302b、心肌肌钙蛋白I（cTnI）及肌酸激酶同工酶（CK-MB）水平变化。应用受试者工作特征（ROC）曲线分析血清miR-302b、cTnI及CK-MB水平对老年AMI的诊断价值。采用Pearson相关性分析，分析老年AMI患者miR-302b水平与cTnI、CK-MB的相关性。结果 AMI组血清miR-302b（4.25±1.30 vs. 0.51±0.16）、cTnI（ng/mL：3.17±1.36 vs. 0.04±0.01）及CK-MB（U/L：73.50±19.36 vs. 11.70±2.25）水平均明显高于对照组（P＜0.01）。ROC曲线分析显示，miR-302b、cTnI及CK-MB诊断AMI的临界值分别为2.73、1.52 ng/mL、61.30 U/L，三项联合诊断老年AMI的AUC最大为0.935，95%CI（0.872～0.985），其敏感度和特异度分别为94.8%和89.2%。相关分析显示，老年AMI患者血清miR-302b水平与cTnI、CK-MB均呈正相关（r=0.826、r=0.745，P＜0.01）。结论血清miR-302b在老年AMI患者中呈高表达，与cTnI、CK-MB联合检测有助于提高老年AMI诊断的准确性。

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	刘肖君
	曾敏
	符秀虹
	何杨利
	陈积雄

关键词 ：急性心肌梗死, miR-302b, 诊断

基金资助:海南省医药卫生科研基金项目（17A400825）

作者简介: 刘肖君（1979-），女，主治医师，E-mail：jzl6534526@163.com。

引用本文:

刘肖君，曾敏，符秀虹，何杨利，陈积雄. 血清miR-302b在老年急性心肌梗死中的表达及其临床意义[J]. 中国急救医学, 2019, 39(7): 678-681.
Liu Xiao-jun, Zeng Min, Fu Xiu-hong, He Yang-li, Chen Ji-xiong. Expression of serum miR-302b in elderly patients with acute myocardial infarction and its clinical significance. Chinese Journal of Critical Care Medicine, 2019, 39(7): 678-681.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2019.07.014 或 http://www.cnemergency.org.cn/CN/Y2019/V39/I7/678

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