摘要 目的 研究应用尿中性粒细胞明胶酶相关载脂蛋白（neutrophil gelatinase-associated apolipoprotein， NGAL）指导的集束化治疗是否能改善脓毒症相关性急性肾损伤（AKI）的预后。 方法 入选尿NGAL>130 ng/mL的脓毒症患者，分为标准治疗组与集束化治疗组，比较两组患者的基础临床特征及相关预后。 结果 ①集束化治疗组与标准治疗组比较，第1天液体输入量更高［（4078±849）mL vs. (2664±828)mL，P＜0.001）］，而第3天液体输入量更少［（2277±733）mL vs. （3086±1056）mL，P＜0.001］；②集束化治疗组与标准治疗组比较，采用保护性机械通气策略的比例更高（100.0% vs. 87.9%，P＜0.001），28 d内机械通气时间更长（22 d vs. 19 d，P＜0.001）；③集束化治疗组与标准治疗组比较，ICU住院时间更短（9.5 d vs. 10.0 d，P=0.002），肾脏替代治疗比例更低（30.9% vs. 45.5%，P=0.014）。 结论 集束化治疗可以缩短脓毒症相关性AKI患者的ICU住院时间，提高肾脏功能康复率。
王晶晶，李竞，王勇强，窦琳. 集束化治疗对脓毒症相关性急性肾损伤的影响[J]. 中国急救医学, 2019, 39(7): 654-658.
Wang Jing-jing, Li Jing, Wang Yong-qiang, Dou Lin. Influence of care bundle on sepsis related acute kidney injury. Chinese Journal of Critical Care Medicine, 2019, 39(7): 654-658.
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