摘要目的: 评价无创机械通气(NIV)对腹部手术后低氧性呼吸衰竭患者气管再插管的影响。方法: 选取在我院ICU治疗的348例腹部手术后7 d内发生低氧性呼吸衰竭的患者,根据随机数字表法,将患者分为两组,即接受NIV治疗组(NIV组,n=173)和标准氧治疗组(标准氧疗组,n=175),治疗从完成随机分组开始共进行30 d或至离开ICU止。比较两组患者气管再插管率、无创通气时间、治疗相关感染发生率与病死率。结果: NIV组患者7 d内再次插管发生率明显低于标准氧疗组[57(32.9%) vs. 80(45.7%),χ2=5.940,P=0.015];与标准氧疗组比较,NIV组患者无创通气时间明显提高[(25.5±4.2)d vs. (20.6±3.8)d,t=11.415,P<0.001],NIV组患者30 d内感染发生率更低[54(31.2%) vs. 86(49.1%),χ2=11.630,P<0.001],NIV组患者7 d内[17(9.8%) vs. 39(22.3%),χ2=10.002,P=0.002]与30 d内[25(14.5%) vs. 52(29.7%),χ2=11.763,P<0.001]肺炎发生率更低。两组患者ICU住院时间与病死率比较差异无统计学意义(均P>0.05)。多变量分析表明,NIV与患者气管再插管负相关(OR=0.496,95%CI 0.231~0.817,P=0.007)。结论: 与标准氧疗比较,NIV能降低腹部手术后低氧性呼吸衰竭患者术后气管插管的风险。
董宏,钱秦娟,张英,费志永,康珍. 无创通气降低腹部手术后呼吸衰竭患者气管再插管风险的研究[J]. 中国急救医学, 2017, 37(11): 1011-1015.
Dong Hong, Qian Qin-juan, Zhang Ying, Fei Zhi-yong, Kang Zhen. Risk of reducing endotracheal reintubation in patients with respiratory failure after abdominal surgery by noninvasive ventilation. Chinese Journal of Critical Care Medicine, 2017, 37(11): 1011-1015.
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