急性呼吸窘迫综合征炎症微环境对调节性T细胞分化的影响

doi:10.3969/j.issn.1002-1949.2019.05.019

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摘要急性呼吸窘迫综合征（acute respiratory distress syndrome， ARDS）/急性肺损伤（acute lung injury， ALI）时，由肺脏结构或功能细胞、免疫细胞（T细胞、B细胞、NK细胞等）、巨噬细胞、中性粒细胞及其分泌（或趋化）的细胞因子/炎症介质所共同构成的一个“炎症微环境”在疾病的发生、发展过程中发挥着重要而复杂的调控作用。调节性T细胞（regulatory T cells，Tregs）是一类功能独特的CD4+T淋巴细胞的亚群，对维持免疫稳态和自我耐受有重要意义，主要参与抑制免疫反应，在ARDS免疫调控中发挥重要作用。从调控Treg细胞分化的机制出发，以细胞因子作为突破，探寻调控ARDS患者体内Treg细胞分化的关键结点，为寻找ARDS潜在治疗靶点提供一个新思路。本文将近年来有关ARDS“炎症微环境”及其参与Treg细胞分化调控的研究进展做一综述。

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	谢珂
	林时辉
	徐昉

关键词 ：急性呼吸窘迫综合征(ARDS）, 急性肺损伤（ALI）, 炎症, 微环境, 调节性T细胞(Tregs）

基金资助:国家自然科学基金（81873928，81801894）；重庆市科委基础科学与前沿技术研究项目（cstc2016jcyjA0005）；重庆市教委科学技术研究项目（KJ1702034）

通讯作者: 徐昉（1977-），男，博士，副教授，硕士生导师，E-mail:xufang828@126.com。

作者简介: 谢珂（1992-），男，硕士研究生，E-mail:495067613@qq.com。

引用本文:

谢珂，林时辉，徐昉. 急性呼吸窘迫综合征炎症微环境对调节性T细胞分化的影响[J]. 中国急救医学, 2019, 39(5): 491-496.
Xie Ke, Lin Shi-hui, Xv Fang. Effect of “inflammation microenvironment” on the differentiation of regulatory T cells in acute respiratory distress syndrome. Chinese Journal of Critical Care Medicine, 2019, 39(5): 491-496.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2019.05.019 或 http://www.cnemergency.org.cn/CN/Y2019/V39/I5/491

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