王飞飞,朱晓萍,马少林. 维生素C在脓毒症中的应用进展[J]. 中国急救医学, 2017, 37(11): 988-991.
Wang Fei-fei, Zhu Xiao-ping, Ma Shao-lin. Advancement in the application of vitamin C in sepsis. Chinese Journal of Critical Care Medicine, 2017, 37(11): 988-991.
[1]曾令勇, 何志兵. 二氯醋酸二异丙胺对脓毒症患者肝功能损害的治疗作用[J]. 华西医学, 2015, 30(2):275-278.
[2]Tyml K. Vitamin C and microvascular dysfunction in systemic inflammation[J]. Antioxidants, 2017, 6(3):1-11.
[3]Wilson JX. Evaluation of vitamin C for adjuvant sepsis therapy [J]. Antioxid Redox Signal, 2013, 19(17):2129-2140.
[4]Rizzo AN, Dudek SM. Endothelial glycocalyx repair: building a wall to protect the lung during sepsis [J]. Am J Respir Cell Mol Biol, 2017, 56(6):687-688.
[5]Stepien KM, Heaton R, Rankin S, et al. Evidence of oxidative stress and secondary mitochondrial dysfunction in metabolic and non-metabolic disorders [J]. J Clin Med, 2017, 6(7):71.
[6]Bernal ME, Varon J, Acosta P, et al. Oxidative stress in critical care medicine [J]. Int J Clin Pract, 2010, 64(11):1480-1488.
[7]Park DW, Zmijewski JW. Mitochondrial dysfunction and immune cell metabolism in sepsis [J]. Infect Chemother, 2017, 49(1):10-21.
[8]Marik PE, Khangoora V, Rivera R, et al. Hydrocortisone, vitamin C, and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study[J]. Chest, 2017, 151(6):1229-1238.
[9]Oudemans-van Straaten HM, Spoelstra-de Man AM, de Waard MC. Vitamin C revisited [J]. Crit Care, 2014, 18(4):460.
[10]May JM, Harrison FE. Role of vitamin C in the function of the vascular endothelium [J]. Antioxid Redox Signal, 2013, 19(17):2068-2083.
[11]May JM. Vitamin C transport and its role in the central nervous system [J]. Subcell Biochem, 2012, 56:85-103.
[12]Fowler AA 3rd, Syed AA, Knowlson S, et al. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis [J]. J Transl Med, 2014, 12:32.
[13]Schorah CJ, Downing C, Piripitsi A, et al. Total vitamin C, ascorbic acid, and dehydroascorbic acid concentrations in plasma of critically ill patients [J]. Am J Clin Nutr, 1996, 63(5):760-765.
[14]Pleiner J, Mittermayer F, Schaller G, et al. High doses of vitamin C reverse escherichia coli endotoxin-induced hyporeactivity to acetylcholine in the human forearm [J]. Circulation, 2002, 106(12):1460-1464.
[15]De Grooth HM, Spoelstra-de Man AME, Oudemans-van Straaten HM. Early plasma vitamin C concentration, organ dysfunction and ICU mortality [J]. Intensive Care Med, 2014, 40(1):S199-200.
[16]Berger MM,Oudemans-van Straaten HM. Vitamin C supplementation in the critically ill patient [J]. Curr Opin Clin Nutr Metab Care, 2015, 18(2):193-201.
[17]Baines M, Shenkin A. Lack of effectiveness of short-term intravenous micronutrient nutrition in restoring plasma antioxidant status after surgery [J]. Clin Nutr, 2002, 21(2):145-150.
[18]Armour J, Tyml K, Lidington D, et al. Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat [J]. J Appl Physiol, 2001, 90(3):795-803.
[19]庞天舒,刘达人,曹利平,等. 脓毒症的抗氧化治疗进展 [J]. 国际外科学杂志, 2013, 40(6):402-404.
[20]Mo SJ, Son EW, Rhee DK, et al. Modulation of TNF-alpha-induced ICAM-1 expression, NO and H2O2 production by alginate, allicin and ascorbic acid in human endothelial cells [J]. Arch Pharm Res, 2003, 26(3):244-251.
[21]Wu F, Wilson JX. Peroxynitrite-dependent activation of protein phosphatase type 2A mediates microvascular endothelial barrier dysfunction [J]. Cardiovasc Res, 2009, 81(1):38-45.
[22]May JM, Qu ZC. Nitric oxide mediates tightening of the endothelial barrier by ascorbic acid[J]. Biochem Biophys Res Commun, 2011, 404(2):701-705.
[23]Ohama T, Brautigan DL. Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A [J]. J Biol Chem, 2010, 285(12):8711-8718.
[24]Zhou G, Kamenos G, Pendem S, et al. Ascorbate protects against vascular leakage in cecal ligation and puncture-induced septic peritonitis [J]. Am J Physiol Regul Integr Comp Physiol, 2012, 302(4):R409-416.
[25]Gaut JP, Belaaouaj A, Byun J, et al. Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation [J]. Free Radic Biol Med, 2006, 40(9):1494-1501.
[26]鲍扬,李维勤,黎介涛. 腹腔感染后微生素A、E、C代谢障碍的防治 [J]. 中华急诊医学杂志, 2006, 15(5):399-401.
[27]Fisher BJ, Seropian IM, Kraskauskas D, et al. Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury [J]. Crit Care Med, 2011, 39(6):1454-1460.
[28]Blumental-Perry A, Bonfield TL. Editorial: Modulation of HMGB1 holds promise for managing sepsis immune paralysis [J]. J Leukoc Biol, 2017, 101(6): 1273-1275.
[29]杨婉,张平安,韩瑞玲. 脓毒症休克患者血浆高迁移率族蛋白B1表达水平动态变化及临床意义[J]. 国际检验医学杂志, 2017 , 38 (4) :433-435,438.
[30]Kim SR, Ha YM, Kim YM, et al. Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals [J]. Biochem Pharmacol, 2015, 95(4):279-289.
[31]吴田田,姚咏明. 脓毒症免疫紊乱及其临床意义[J]. 解放军医学杂志, 2017, 42(2):95-102.
[32]Jeong YJ, Kim JH, Hong JM, et al. Vitamin C treatment of mouse bone marrow-derived dendritic cells enhanced CD8(+) memory T cell production capacity of these cells in vivo [J]. Immunobiology, 2014, 219(7):554-564.
[33]Gao YL, Lu B, Zhai JH, et al. The parenteral vitamin C improves sepsis and sepsis-induced multiple organ dysfunction syndrome via preventing cellular immunosuppression [J]. Mediators Inflamm, 2017, 2017:4 024 672.
[34]Wagner SC, Markosian B, Ajili N, et al. Intravenous ascorbic acid as an adjuvant to interleukin-2 immunotherapy [J]. J Transl Med, 2014, 12:127.
[35]Carr AC, Shaw GM, Fowler AA, et al. Ascorbate-dependent vasopressor synthesis: a rationale for vitamin C administration in severe sepsis and septic shock [J]. Crit Care, 2015, 19:418.
[36]May JM, Qu ZC, Nazarewicz R, et al. Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine [J]. Brain Res Bull, 2013, 90:35-42.
[37]Zabet MH, Mohammadi M, Ramezani M, et al. Effect of high-dose Ascorbic acid on vasopressor′s requirement in septic shock [J]. J Res Pharm Pract, 2016, 5(2):94-100.
[38]Padayatty SJ, Sun H, Wang Y, et al. Vitamin C pharmacokinetics: implications for oral and intravenous use [J]. Ann Intern Med, 2004, 140(7):533-537.
[39]Long CL, Maull KI, Krishnan RS, et al. Ascorbic acid dynamics in the seriously ill and injured [J]. J Surg Res, 2003, 109(2):144-148.
[40]Swarbreck SB, Secor D, Ellis CG, et al. Short-term effect of ascorbate on bacterial content, plasminogen activator inhibitor-1, and myeloperoxidase in septic mice [J]. J Surg Res, 2014, 191(2):432-440.
[41]Thomas LD, Elinder CG, Tiselius HG, et al. Ascorbic acid supplements and kidney stone incidence among men: a prospective study [J]. JAMA Intern Med, 2013, 173(5):386-388.
[42]Du J, Cullen JJ, Buettner GR. Ascorbic acid: chemistry, biology and the treatment of cancer [J]. Biochim Biophys Acta, 2012, 1826(2):443-457.
[43]Padayatty SJ, Sun H, Wang Y, et al. Vitamin C pharmacokinetics: implications for oral and intravenous use [J]. Ann Intern Med, 2004, 140(7):533-537.
[44]Muhlhofer A, Mrosek S, Schlegel B, et al. High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers [J]. Eur J Clin Nutr, 2004, 58(8):1151-1158.
[45]Koekkoek WA, van Zanten AR. Antioxidant vitamins and trace elements in critical illness[J]. Nutr Clin Pract, 2016, 31(4):457-474.
[46]Carlson D, Maass DL, White DJ, et al. Antioxidant vitamin therapy alters sepsis-related apoptotic myocardial activity and inflammatory responses [J]. Am J Physiol Heart Circ Physiol, 2006, 291(6):H2779-2789.
[47]Howe KP, Clochesy JM, Goldstein LS, et al. Mechanical ventilation antioxidant trial [J]. Am J Crit Care, 2015, 24(5):440-445.
[48]Kim JY, Lee SM. Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis [J]. Eur J Pharmacol, 2006, 534(1-3):202-209.