炎性指标在急性A型主动脉夹层中不同性别患者中的差异及与院内病死率的相关性

doi:10.3969/j.issn.1002-1949.2019.04.012

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摘要目的探讨炎性指标在急性A型主动脉夹层（type A aortic dissection, AAD）不同性别患者中的差异及与院内病死率的相关性。方法选取2015年1月至2017年12月中南大学湘雅二医院急性AAD住院患者，分为男性组与女性组，对两组患者的年龄、既往史、入院时白细胞计数（WBC）、中性粒细胞比值、C-反应蛋白（CRP），治疗方式及院内生存情况进行统计分析。结果 463例患者中男363例，女100例，男女比为3.63∶1，女性发病年龄大于男性（岁：54.6±10.9 vs. 48.6±11.2，P＜0.05），合并冠心病患者比例高于男性，男性吸烟者多于女性。炎性指标、手术治疗在男性存活组和死亡组之间差异有统计学意义（P＜0.05），二元Logistic回归结果显示，CRP（OR=0.429，P=0.01）、手术治疗（OR=0.108，P＜0.001）与男性急性AAD院内死亡负相关（P＜0.05）；女性死亡组年龄大于存活组（P＜0.05），吸烟者人数多于存活组（P＜0.05），但年龄、炎性指标、治疗方式与女性院内死亡无独立相关。结论急性AAD男性较女性常见，男性发病年龄较女性小，CRP、手术治疗为男性急性AAD患者的保护因素。

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	周阳
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	盛丽娟

关键词 ：主动脉夹层, 炎性指标, C-反应蛋白（CRP）, 性别差异

通讯作者: 柴湘平(1969-)，男，主任医师，博士生导师，E-mail:chaixiangping@csu.edu.cn。

作者简介: 周阳(1990-)，男，硕士，E-mail:345060078@qq.com。

引用本文:

周阳，柴湘平，杨贵芳，彭文，贺华平，盛丽娟. 炎性指标在急性A型主动脉夹层中不同性别患者中的差异及与院内病死率的相关性[J]. 中国急救医学, 2019, 39(4): 351-354.
Zhou Yang, Chai Xiang-ping, Yang Gui-fang, Peng Wen, He Hua-ping, Sheng Li-juan. Correlation between gender-related differences of inflammatory biomarkers and in-hospital mortality among patients with acute Stanford type A aortic dissection. Chinese Journal of Critical Care Medicine, 2019, 39(4): 351-354.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2019.04.012 或 http://www.cnemergency.org.cn/CN/Y2019/V39/I4/351

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