严重创伤患者纤溶异常的研究进展

doi:10.3969/j.issn.1002-1949.2019.02.021

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摘要创伤发生后人体的凝血系统会大量激活，但至少有四分之一的创伤患者会出现创伤性凝血病，且此类患者常伴有纤溶异常，引起病死率升高，预后变差。纤溶异常包括纤溶关闭和纤溶亢进，前者纤溶能力降低，患者血栓形成风险提高；后者纤溶过剩，患者常伴有大出血。除了常规凝血检查外，纤溶异常的诊断主要依靠粘弹性凝血功能检测。本文将对纤溶异常的最新实验结果和研究进展进行总结，希望能为严重创伤患者纤溶异常的诊断和治疗提供新的思路。

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	封启明

关键词 ：纤溶关闭, 纤溶亢进, 创伤性凝血病（TIC）, 血栓弹力图（TEG）

通讯作者: 封启明（1966-），女，博士，主任医师，硕士生导师，急诊科主任，E-mail：fengqiming04@126.com。

作者简介: 徐文心（1991-），女，硕士研究生，E-mail:wenxin419@sina.cn。

引用本文:

徐文心，封启明. 严重创伤患者纤溶异常的研究进展[J]. 中国急救医学, 2019, 39(2): 196-200.
Xu Wen-xin, Feng Qi-ming. The advances of fibrinolytic abnormalities in severe trauma patients. Chinese Journal of Critical Care Medicine, 2019, 39(2): 196-200.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2019.02.021 或 http://www.cnemergency.org.cn/CN/Y2019/V39/I2/196

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