细胞周期阻滞标志物在早期急性肾损伤中应用的研究进展

doi:10.3969/j.issn.1002-1949.2019.02.017

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摘要急性肾损伤（acute kidney injury, AKI）明显影响患者的临床预后，其发病机制不清，且临床缺乏有效的治疗手段，缺少可早期预测AKI发生的标志物。肌酐作为目前诊断手段既缺乏敏感度，也缺少特异度。临床迫切需要能够早期准确地预测肾功能损伤的生物学标志物。最近的研究表明,细胞周期停滞可能与AKI的发生密切相关。细胞周期停滞时产生的尿基质金属蛋白酶（TIMP-2）和胰岛素样生长因子结合蛋白（IGFBP-7）可在早期准确预测AKI的发生。

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	金魁
	付阳阳
	徐军
	于学忠

关键词 ：急性肾损伤（AKI）, 基质金属蛋白酶（TIMP-2）, 胰岛素样生长因子结合蛋白（IGFBP-7）, 细胞周期停滞, 标志物, 尿, 血肌苷（SCr）

基金资助:中国医学科学院医学与健康科技创新工程项目(2017-12M-1-009)

通讯作者: 徐军（1979-），男，博士，副主任医师，E-mail：xujunfree@126.com； 于学忠（1958-），男，博士，主任医师，E-mail：yxz@medmail.com.cn。

作者简介: 金魁（1981-），男，博士，副主任医师,E-mail: yuese9213@163.com。

引用本文:

金魁，付阳阳，徐军，于学忠. 细胞周期阻滞标志物在早期急性肾损伤中应用的研究进展[J]. 中国急救医学, 2019, 39(2): 184-188.
Jin Kui, Fu Yang-yang, Xu Jun, Yu Xue-zhong. The development of cell cycle arrest biomarkers in acute kidney injury. Chinese Journal of Critical Care Medicine, 2019, 39(2): 184-188.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2019.02.017 或 http://www.cnemergency.org.cn/CN/Y2019/V39/I2/184

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