促红细胞生成素对脑出血神经保护作用的研究进展

doi:10.3969/j.issn.1002-1949.2018.11.018

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摘要促红细胞生成素(erythropoietin， EPO)是一种含唾液酸的酸性糖蛋白，是人体内源性的一种生理活性物质，传统观点认为，EPO促进晚期红系祖细胞的繁殖、分化和成熟。近年来越来越多的研究表明，EPO具有神经保护作用，其机制可能包括抑制炎症反应和水肿、抗凋亡、抑制兴奋性氨基酸的毒性作用、营养神经等。根据来源可分为内源性和外源性EPO。有动物实验已证实，外源性EPO可通过血脑屏障(blood-brain barrier， BBB)进而在脑内发挥神经保护作用。本文主要就EPO对脑出血（intracerebral hemorrhage， ICH）后发挥脑保护作用机制的研究进展作一综述。

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	李强
	黄亮

关键词 ：促红细胞生成素（EPO), 脑出血（ICH）, 神经保护

基金资助:江西省自然科学基金（20132BAB205057）

通讯作者: 黄亮（1963-），男，主任医师，教授， E-mail: HuangLiang6312@sina.com。

作者简介: 李强（1991-），男，硕士，住院医师， E-mail:287207006@qq.com。

引用本文:

李强，黄亮. 促红细胞生成素对脑出血神经保护作用的研究进展[J]. 中国急救医学, 2018, 38(11): 1009-1012.
Li Qiang, Huang Liang. Reseach advances in the neuroprotective effects of erythropoietin on intracerebral hemorrhage. Chinese Journal of Critical Care Medicine, 2018, 38(11): 1009-1012.

链接本文:

http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2018.11.018 或 http://www.cnemergency.org.cn/CN/Y2018/V38/I11/1009

［1］Balaban′yan VY, UL′yanov AM, Elizarova OS, et al. Targeted transport of low-sialylated recombinant human erythropoietin by polymer nanoparticles through the blood-brain barrier.［J］. Russ J Gener Chem, 2013, 83(12):2571-2577. ［2］Chau M, Chen D, Wei L. Erythropoietin attenuates inflammatory factors and cell death in neonatal rats with intracerebral hemorrhage［J］. Acta Neurochir Suppl, 2011, 111:299-305. ［3］石秋艳, 李倩, 姜进克,等. 促红细胞生成素对大鼠脑出血炎症反应的抑制作用及机制［J］. 中国康复医学杂志, 2009, 24(8):727-730.［4］Solling C. Organ-protective and immunomodulatory effects of erythropoietin-an update on recent clinical trials［J］. Basic Clin Pharmacol Toxicol, 2012, 110(2):113-121. ［5］Yu Z, Tang L, Chen L, et al. Erythropoietin reduces brain injury after intracerebral hemorrhagic stroke in rats［J］. Mol Med Rep, 2013, 8(5):1315-1322. ［6］Yang ML, Tao T, Xu J, et al. Antiapoptotic effect of gene therapy with recombinant adenovirus vector containing hypoxia-inducible factor-1α after cerebral ischemia and reperfusion in rats［J］. Chin Med J, 2017, 130(7):1700-1706. ［7］Wang Q, Zhang L, Yuan X, et al. The Relationship between the Bcl-2/Bax Proteins and the Mitochondria-Mediated Apoptosis Pathway in the Differentiation of Adipose-Derived Stromal Cells into Neurons［J］. PloS One, 2016, 11(10):e0 163 327. ［8］韩凤,李丛言,关雪莲,等. 大鼠脑出血周边组织caspase-3表达和细胞凋亡的变化及促红细胞生成素的影响［J］. 中风与神经疾病杂志, 2013, 30(8):707-709. ［9］梁俊君,王亚冰,辛海滨,等. rhEPO通过调节JAK2/STAT5信号通路减少大鼠脑出血后神经细胞凋亡［J］.中国当代医药, 2017, 24(16):8-12. ［10］姜进克,石秋艳,何芳. 促红细胞生成素对脑出血大鼠的神经保护作用和机制探讨［J］.中国现代医生, 2013, 51(3):1-3. ［11］Han F, Cong-Yang LI, Guan XL. Expression changes of caspase-3 and apoptosis around hematoma on acute intracerebral hemorrhage(ICH) in rats,and the effect of erythropoietin( EPO)［J］. J Apopl Nerv Dis, 2013, 30(8):707-709. ［12］Chen G, Zhang S, Shi J, et al. Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage［J］. Cytokine, 2009, 45(3):162-168. ［13］祝春华, 张祥建. 脑出血后病理生理机制及临床治疗对策［J］. 中国神经免疫学和神经病学杂志, 2012, 19(3):167-169. ［14］Duan X, Wen Z, Shen H, et al. Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy［J］. Oxid Med Cell Longev, 2016, 2016:1 203 285. ［15］Al-Sarraf H, Malatiali S, Al-Awadi M, et al. Effects of erythropoietin on astrocytes and brain endothelial cells in primary culture during anoxia depend on simultaneous signaling by other cytokines and on duration of anoxia［J］. Neurochem Int, 2018, 113:34-45. ［16］Liu J, Narasimhan P, Yu F, et al. Neuroprotection by hypoxic preconditioning involves oxidative stress-mediated expression of hypoxia-inducible factor and erythropoietin［J］. Stroke, 2005, 36(6):1264-1269. ［17］Mric＇-Pelcic J, Pilipovic K, Pelcic G, et al. Decrease in Oxidative Stress Parameters after Post-Ischaemic Recombinant Human Erythropoietin Administration in the Hippocampus of Rats Exposed to Focal Cerebral Ischaemia［J］. Basic Clin Pharmacol Toxicol, 2017, 121(6):453-464. ［18］Zhang J, Zhu Y, Zhou D, et al. Recombinant human erythropoietin (rhEPO) alleviates early brain injury following subarachnoid hemorrhage in rats: possible involvement of Nrf2-ARE pathway［J］. Cytokine, 2010, 52(3):252-257. ［19］车玉琴,孙晓红.EPO对脑出血大鼠脑组织氧自由基损害的保护作用［J］.中国血液流变学杂志, 2009, 19(2):178-180,205. ［20］Kertmen H, Gürer B, Yilmaz ER, et al. The comparative effects of recombinant human erythropoietin and darbepoetin-alpha on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit［J］. Acta Neurochir(Wien), 2014, 156(5):951-962. ［21］Lourhmati A, Buniatian GH, Paul C, et al. Age-dependent astroglial vulnerability to hypoxia and glutamate: the role for erythropoietin［J］. PloS One, 2013, 8(10):e77 182. ［22］侯丽淳,关雪莲,韩凤,等.促红细胞生成素对大鼠脑出血周边组织谷氨酸及脑水含量的影响［J］.中风与神经疾病杂志, 2012, 29(2):140-142. ［23］Yu X, Shacka JJ, Eells JB, et al. Erythropoietin receptor signalling is required for normal brain development［J］. Development, 2002, 129(2):505-516. ［24］Helbok R， Shaker E, Beer R，et al. High dose Erythropoietin increases Brain Tissue Oxygen Tension in Severe Vasospasm after Subarachnoid Hemorrhage［J］. BMC Neurol, 2012, 12:32. ［25］Cruz Navarro J, Pillai S, Ponce LL, et al. Endothelial nitric oxide synthase mediates the cerebrovascular effects of erythropoietin in traumatic brain injury［J］. Front Immunol, 2014, 5:494. ［26］Wang L, Zhang Z, Wang Y, et al. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats［J］. Stroke, 2004, 35(7):1732-1737. ［27］陈达,王斯闻,朱杰，等.促红细胞生成素对脑出血神经生长因子表达的影响［J］.中国医学工程, 2010, 18(4):41-42. ［28］Li Y, Ogle ME, Wallace GC, et al. Erythropoietin attenuates intracerebral hemorrhage by diminishing matrix metalloproteinases and maintaining blood-brain barrier integrity in mice［J］. Acta Neurochir Suppl, 2008, 105:105-112. ［29］Tang Y, Wu P, Su J, et al. Effects of Aquaporin-4 on edema formation following intracerebral hemorrhage［J］. Exp Neurol, 2010, 223(2):485-495. ［30］Chu H, Ding H, Tang Y, et al. Erythropoietin protects against hemorrhagic blood brain barrier disruption through the effects of aquaporin-4［J］.Lab Invest, 2014, 94(9):1042-1053. ［31］刘坤,姚阳,杨宇,等.促红细胞生成素预处理对脑缺血再灌注大鼠水通道蛋白4的影响［J］.中风与神经疾病杂志, 2014, 31(2):111-113.