线粒体Sirt3活化在重症失血性休克发展进程中的作用

doi:10.3969/j.issn.1002-1949.2018.11.017

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摘要 Sirt3作为线粒体的一种去乙酰化酶，通过调节多种分子的去乙酰化，可缓解重症失血性休克发展过程中发生的血管低反应性、血管高通透性，降低氧化应激，抑制细胞坏死与凋亡，减轻线粒体损伤，发挥组织与细胞保护作用。本文综述Sirt3活化在重症失血性休克发展进程中的作用，希望针对Sirt3为防治重症失血性休克提供新的思路。

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	王齐
	赵自刚
	牛春雨

关键词 ： Sirt3, 失血性休克, 血管反应性, 血管通透性, 氧化应激

基金资助:河北省自然科学基金(H2015405041)

通讯作者: 牛春雨（1967-），男，博士，教授，E-mail: ncylxf@126.com。赵自刚（1974-），男，博士，教授，E-mail: zzghyl@126.com。

作者简介: 王齐（1992-），女，硕士，E-mail: 421495759@qq.com。

引用本文:

王齐，赵自刚，牛春雨. 线粒体Sirt3活化在重症失血性休克发展进程中的作用[J]. 中国急救医学, 2018, 38(11): 1005-1008.
Wang Qi, Zhao Zi-Gang, Niu Chun-Yu. Role of mitochondrial Sirt3 activation during severe hemorrhagic shock. Chinese Journal of Critical Care Medicine, 2018, 38(11): 1005-1008.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2018.11.017 或 http://www.cnemergency.org.cn/CN/Y2018/V38/I11/1005

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