他汀类药物在脓毒症相关急性呼吸窘迫综合征中应用的研究进展

doi:10.3969/j.issn.1002-1949.2018.09.018

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摘要目前，脓毒症相关急性呼吸窘迫综合征(adult respiratory distress syndrome， ARDS)的治疗研究进展甚微，但它却是导致重症感染患者主要的死因之一。他汀类药物是临床上最常用的降脂药物，它的抗炎、免疫调节和抗氧化等多效性也备受关注，其多效性与脓毒症相关ARDS的发病机制存在诸多相关性，本文就他汀类药物在脓毒症相关ARDS治疗方面的研究进行综述。 

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	邱敏珊
	蔡立华
	陈洁
	邵汉权
	沈利汉

关键词 ：他汀类药物, 脓毒症, 急性呼吸窘迫综合征(ARDS)

作者简介: 邱敏珊（1989-），女，硕士，住院医师， E-mail：missa157@163.com。

引用本文:

邱敏珊，蔡立华，陈洁，邵汉权，沈利汉. 他汀类药物在脓毒症相关急性呼吸窘迫综合征中应用的研究进展[J]. 中国急救医学, 2018, 38(9): 823-826.
Qiu Min-shan, Cai Li-hua, Chen Jie, Shao Han-quan, Shen Li-han. Research progress on the application of statins in sepsis associated adult respiratory distress syndrome. Chinese Journal of Critical Care Medicine, 2018, 38(9): 823-826.

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http://www.cnemergency.org.cn/CN/10.3969/j.issn.1002-1949.2018.09.018 或 http://www.cnemergency.org.cn/CN/Y2018/V38/I9/823

［1］Li WC, Zou ZJ, Zhou MG, et al. Effects of simvastatin on the expression of inducible NOS in acute lung injury in septic rats［J］. Int J Clin Exp Pathol, 2015, 8(11): 15 106-15 111. ［2］Bernal E, Marín I, Masiá M, et al. Statins in HIV-Infected Patients: Potential Beneficial Effects and Clinical Use［J］. AIDS Rev, 2017, 19(2):59-71. ［3］Oesterle A, Laufs U, Liao JK. Pleiotropic Effects of Statins on the Cardiovascular System［J］. Circ Res, 2017, 120(1):229-243. ［4］Ference BA, Ginsberg HN, Graham I, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel［J］. Eur Heart J, 2017, 38(32):2459-2472. ［5］王金波，程国杰，曹树军，等.急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入治疗术前高剂量瑞舒伐他汀对炎性因子和心肌灌注的影响［J］.临床急诊杂志， 2016, 10(2):136. ［6］郑玉强，钱东去. 不同剂量瑞舒伐他汀治疗对ACS急诊PCI术后心脏保护作用的研究［J］.临床急诊杂志， 2016, 10(7):553. ［7］Yusuf S, Bosch J, Dagenais G, et al. Cholesterol lowering in intermediate-risk persons without cardiovascular disease［J］. N Engl J Med, 2016, 374(21):2021-2031. ［8］血脂异常老年人使用他汀类药物中国专家共识组. 血脂异常老年人使用他汀类药物中国专家共识［J］. 中华内科杂志, 2015, 54(5):467-477. ［9］Shankar-Hari M, Phillips GS, Levy ML, et al. Developing a new definition and assessing new clinical criteria for septic shock: for the third international consensus definitions for sepsis and septic shock (sepsis-3)［J］. JAMA, 2016, 315(8): 775-787. ［10］Moussa MD, Santonocito C, Fagnoul D, et al. Evaluation of endothelial damage in sepsis-related ARDS using circulating endothelial cells［J］. Intensive Care Med, 2015, 41(2): 231-238. ［11］Li H, Zhou X, Tan H, et al. Neutrophil extracellular traps contribute to the pathogenesis of acid-aspiration-induced ALI/ARDS［J］. Oncotarget, 2017, 9(2):1772-1784. ［12］Sheu CC, Gong MN, Zhai R, et al. Clinical characteristics and outcomes of sepsis-related vs non-sepsis-related ARDS［J］. Chest, 2010, 138(3): 559-567. ［13］Yu Y, Cui Y, Zhao Y, et al. The binding capability of plasma phospholipid transfer protein, but not HDL pool size, is critical to repress LPS induced inflammation［J］. Sci Rep, 2016, 6（9）:20 845. ［14］Palomares O, Akdis M, Martín-Fontecha M, et al. Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells［J］. Immunol Rev, 2017, 278(1):219-236. ［15］Tousoulis D, Psarros C, Demosthenous M, et al. Innate and adaptive inflammation as a therapeutic target in vascular disease: the emerging role of statins［J］. J Am Coll Cardiol, 2014, 63(23): 2491-2502. ［16］Psarros C, Economou EK, Koutsilieris M, et al. Statins as pleiotropic modifiers of vascular oxidative stress and inflammation［J］. J Crit Care Med (Targu Mures), 2015, 1(2): 43-54. ［17］Margaritis M, Sanna F, Antoniades C. Statins and oxidative stress in the cardiovascular system［J］. Curr Pharm Des, 2017, 23(9):7040-7047. ［18］Margaritis M, Channon KM, Antoniades C. Statins as regulators of redox state in the vascular endothelium: beyond lipid lowering［J］. Antioxid Redox Signal, 2014, 20(8): 1198-1215. ［19］Loughran P A, Lei Z, Xu L, et al. Nitric Oxide in Sepsis and Hemorrhagic Shock: Beneficial or Detrimental［M］. Nitric Oxide, 2017: 289-300. ［20］Xia T, Guan W, Fu J, et al. Tirofiban induces vasorelaxation of the coronary artery via an endothelium-dependent NO-cGMP signaling by activating the PI3K/Akt/eNOS pathway［J］. Biochem Biophys Res Commun, 2016, 474(3): 599-605. ［21］Undas A, Brummel-Ziedins KE, Mann KG. Anticoagulant effects of statins and their clinical implications［J］. Thromb Haemost, 2014, 111(3): 392-400. ［22］Jacobson JR, Barnard JW, Grigoryev DN, et al. Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury［J］. Am J Physiol Lung Cell Mol Physiol, 2005, 288(6): L1026-L1032. ［23］Takano K, Yamamoto S, Tomita K, et al. Successful treatment of acute lung injury with pitavastatin in septic mice: potential role of glucocorticoid receptor expression in alveolar macrophages［J］. J Pharmacol Exp Ther, 2011, 336(2): 381-390. ［24］Shyamsundar M, McKeown STW, O′Kane CM, et al. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers［J］. Am J Respir Crit Care Med, 2009, 179(12): 1107-1114. ［25］Mansur A, Steinau M, Popov AF, et al. Impact of statin therapy on mortality in patients with sepsis-associated acute respiratory distress syndrome(ARDS) depends on ARDS severity: a prospective observational cohort study［J］. BMC Med, 2015, 13(1):128. ［26］Dinglas VD, Hopkins RO, Wozniak AW, et al. One-year outcomes of rosuvastatin versus placebo in sepsis-associated acute respiratory distress syndrome: prospective follow-up of SAILS randomised trial［J］. Thorax, 2016, 71(5):401-410. ［27］Truwit JD, Bernard GR, Steingrub J, et al. Rosuvastatin for sepsis-associated acute respiratory distress syndrome［J］. N Engl J Med, 2014, 370(23): 2191-2200. ［28］Rhodes A, Evans LE, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016［J］. Crit Care Med, 2017, 45(3):486-552.